Human Iba1 / AIF-1 Protein, His Tag

表達(dá)區(qū)間及表達(dá)系統(tǒng)（Source）

Human Iba1, His Tag (IB1-H51H9) is expressed from E. coli cells. It contains AA Met 1 - Pro 147 (Accession # P55008-1).

Predicted N-terminus: Met 1

蛋白結(jié)構(gòu)（Molecular Characterization）

This protein carries a polyhistidine tag at the C-terminus.

The protein has a calculated MW of 18.6 kDa. The protein migrates as 18-20 kDa under reducing (R) condition (SDS-PAGE).

內(nèi)毒素（Endotoxin）

Less than 1.0 EU per μg by the LAL method.

純度（Purity）

>95% as determined by SDS-PAGE.

制劑（Formulation）

Lyophilized from 0.22 μm filtered solution in PBS, pH7.4. Normally trehalose is added as protectant before lyophilization.

Contact us for customized product form or formulation.

重構(gòu)方法（Reconstitution）

Please see Certificate of Analysis for specific instructions.

For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

存儲(chǔ)（Storage）

For long term storage, the product should be stored at lyophilized state at -20°C or lower.

Please avoid repeated freeze-thaw cycles.

This product is stable after storage at:

-20°C to -70°C for 12 months in lyophilized state;

-70°C for 3 months under sterile conditions after reconstitution.

背景（Background）

同種異體炎性因子1（AIF1），也稱為IBA1、daintain和蛋白G1，是一種肌動(dòng)蛋白結(jié)合蛋白。肌動(dòng)蛋白結(jié)合蛋白，增強(qiáng)膜皺縮和RAC激活。增強(qiáng)LCP1的肌動(dòng)蛋白捆綁活性。結(jié)合鈣。在RAC信號(hào)傳導(dǎo)和吞噬作用中起作用?？赡茉诰奘杉?xì)胞活化和功能中發(fā)揮作用。促進(jìn)血管平滑肌細(xì)胞和T淋巴細(xì)胞的增殖。增強(qiáng)淋巴細(xì)胞遷移。在血管炎癥中起作用。