Human JAB1 / COPS5 Protein, Fc Tag
分子別名(Synonym)
JAB1,COPS5
表達區(qū)間及表達系統(tǒng)(Source)
Human JAB1 Protein, Fc Tag (JA1-H5553) is expressed from Baculovirus-Insect cells. It contains AA Ala 2 - Ser 334 (Accession # Q92905-1).
Predicted N-terminus: Ala 2
蛋白結(jié)構(gòu)(Molecular Characterization)
This protein carries a human IgG1 Fc tag at the C-terminus.
The protein has a calculated MW of 63.9 kDa. The protein migrates as 33 kDa and 64-66 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
內(nèi)毒素(Endotoxin)
Less than 1.0 EU per μg by the LAL method.
純度(Purity)
>90% as determined by SDS-PAGE.
制劑(Formulation)
Lyophilized from 0.22 μm filtered solution in PBS, pH7.4 with trehalose as protectant.
Contact us for customized product form or formulation.
重構(gòu)方法(Reconstitution)
Please see Certificate of Analysis for specific instructions.
For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.
存儲(Storage)
For long term storage, the product should be stored at lyophilized state at -20°C or lower.
Please avoid repeated freeze-thaw cycles.
This product is stable after storage at:
-20°C to -70°C for 12 months in lyophilized state;
-70°C for 3 months under sterile conditions after reconstitution.
背景(Background)
Jab1,也稱為CSN5,是(COP9)信號體復(fù)合體(CSN)的一個組成部分,據(jù)報道參與細胞增殖、細胞周期進程和腫瘤發(fā)生的調(diào)節(jié)。作為COP9信號體復(fù)合體的一個組成部分,Jab1可以相互調(diào)節(jié)MED1的穩(wěn)定性和轉(zhuǎn)錄活性,可能是介導(dǎo)HER2+腫瘤侵襲性表型的MED1直接靶基因。
關(guān)鍵字: JAB1;JAB1蛋白;JAB1重組蛋白;ACRO;百普賽斯;
百普賽斯集團ACROBiosystems Group(股票代碼:301080)是成立于2010年的跨國生物科技公司,是為全球生物醫(yī)藥、健康產(chǎn)業(yè)領(lǐng)域提供關(guān)鍵生物試劑產(chǎn)品及解決方案的行業(yè)平臺型基石企業(yè)。2021年在創(chuàng)業(yè)板上市。百普賽斯集團業(yè)務(wù)遍布全球,橫跨亞洲、北美洲、歐洲,在中國、美國、瑞士等12個城市設(shè)有辦公室、研發(fā)中心及生產(chǎn)基地。目前累計服務(wù)客戶超6000家,與全球Top 20醫(yī)藥企業(yè)均建立了長期、穩(wěn)定的合作伙伴關(guān)系。集團旗下?lián)碛衅放艫CROBiosystems百普賽斯、bioSeedin柏思薈、Condense Capital墾拓資本和ACRODiagnostics百斯醫(yī)學(xué)等。