Rat Clec4b2 Protein, His Tag

表達(dá)區(qū)間及表達(dá)系統(tǒng)（Source）

Rat Clec4b2 Protein, His Tag (CLB-R5246) is expressed from human 293 cells (HEK293). It contains AA Gln 42 - Leu 208 (Accession # F1M7G4-1).

Predicted N-terminus: His

蛋白結(jié)構(gòu)（Molecular Characterization）

This protein carries a polyhistidine tag at the N-terminus.

The protein has a calculated MW of 21.6 kDa. The protein migrates as 27-40 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE) due to glycosylation.

內(nèi)毒素（Endotoxin）

Less than 1.0 EU per μg by the LAL method.

純度（Purity）

>90% as determined by SDS-PAGE.

制劑（Formulation）

Lyophilized from 0.22 μm filtered solution in PBS, pH7.4 with trehalose as protectant.

Contact us for customized product form or formulation.

重構(gòu)方法（Reconstitution）

Please see Certificate of Analysis for specific instructions.

For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

存儲（Storage）

For long term storage, the product should be stored at lyophilized state at -20°C or lower.

Please avoid repeated freeze-thaw cycles.

This product is stable after storage at:

-20°C to -70°C for 12 months in lyophilized state;

-70°C for 3 months under sterile conditions after reconstitution.

背景（Background）

CLEC4B2（C型凝集素結(jié)構(gòu)域家族4，成員b2），也稱為樹突狀細(xì)胞免疫活化受體1（DCAR1）和抗原呈遞細(xì)胞凝集素樣受體A1（APLRA1），是一種屬于細(xì)胞表面C型凝集素域家族的II型膜蛋白。CLEC4B2在宿主防御中可能扮演第二個角色。Clec4b2是免疫系統(tǒng)細(xì)胞上的一種功能性受體，為CLR調(diào)節(jié)免疫反應(yīng)提供了進(jìn)一步的見解。CLEC4B2是對真菌感染和損傷的先天免疫反應(yīng)所特別需要的，并且將這種GPCR放置在秀麗隱桿線蟲表皮中先天免疫識別和信號傳導(dǎo)的任何其他已知成分的上游。