Serpin F1產(chǎn)品信息
英文名稱:Pigment epithelium-derived factor
中文名稱:色素上皮衍生因子
靶點別稱:Serpin F1
物種:Human
標簽:His Tag
屬性:Protein
標記:Unconjugated
表達區(qū)間及表達系統(tǒng)(Source)
Human Serpin F1, His Tag (SE1-H5221) is expressed from human 293 cells (HEK293). It contains AA Gln 20 - Pro 418 (Accession # NP_002606).
Predicted N-terminus: Gln 20
蛋白結(jié)構(gòu)(Molecular Characterization)
This protein carries a polyhistidine tag at the C-terminus
The protein has a calculated MW of 45.2 kDa. The protein migrates as 45-60 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
內(nèi)毒素(Endotoxin)
Less than 1.0 EU per μg by the LAL method.
純度(Purity)
>95% as determined by SDS-PAGE.
制劑(Formulation)
Lyophilized from 0.22 μm filtered solution in PBS, pH7.4 with trehalose as protectant.
Contact us for customized product form or formulation.
重構(gòu)方法(Reconstitution)
Please see Certificate of Analysis for specific instructions.
For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.
存儲(Storage)
For long term storage, the product should be stored at lyophilized state at -20°C or lower.
Please avoid repeated freeze-thaw cycles.
This product is stable after storage at:
-20°C to -70°C for 12 months in lyophilized state;
-70°C for 3 months under sterile conditions after reconstitution.
背景(Background)
erpin F1(SERPINF1)也被稱為色素上皮衍生因子(PEDF)、細胞增殖誘導(dǎo)基因35蛋白(PIG35)。Serpin F1屬于Serpin家族。Serpin F1在靜止細胞中表達。PEDF具有多種功能,包括抗血管生成、抗腫瘤和神經(jīng)營養(yǎng)特性。SERPINF1/PEDF抑制內(nèi)皮細胞遷移。PEDF/SERPINF1抑制視網(wǎng)膜新生血管和內(nèi)皮細胞增殖。PEDF還通過p38 MAPK通路或FAS/FASL通路負責(zé)內(nèi)皮細胞的凋亡。PEDF還具有神經(jīng)營養(yǎng)功能。
關(guān)鍵字: Serpin F1;Serpin F1蛋白;Serpin F1重組蛋白;ACRO;百普賽斯;
百普賽斯集團ACROBiosystems Group(股票代碼:301080)是成立于2010年的跨國生物科技公司,是為全球生物醫(yī)藥、健康產(chǎn)業(yè)領(lǐng)域提供關(guān)鍵生物試劑產(chǎn)品及解決方案的行業(yè)平臺型基石企業(yè)。2021年在創(chuàng)業(yè)板上市。百普賽斯集團業(yè)務(wù)遍布全球,橫跨亞洲、北美洲、歐洲,在中國、美國、瑞士等12個城市設(shè)有辦公室、研發(fā)中心及生產(chǎn)基地。目前累計服務(wù)客戶超6000家,與全球Top 20醫(yī)藥企業(yè)均建立了長期、穩(wěn)定的合作伙伴關(guān)系。集團旗下?lián)碛衅放艫CROBiosystems百普賽斯、bioSeedin柏思薈、Condense Capital墾拓資本和ACRODiagnostics百斯醫(yī)學(xué)等。