CD109產(chǎn)品信息
英文名稱：DNA polymerase alpha subunit
中文名稱：DNA聚合酶α亞基
靶點別稱：CD109,CPAMD7
物種：Human
標簽：His Tag & Avi Tag
屬性：Protein
標記：Biotin-labeled
表達區(qū)間及表達系統(tǒng)（Source）
Biotinylated Human CD109, His,Avitag (CD9-H82E4) is expressed from human 293 cells (HEK293). It contains AA Val 22 - Ser 1269 (Accession # Q6YHK3-1).
蛋白結(jié)構(gòu)（Molecular Characterization）
This protein carries a polyhistidine tag at the C-terminus, followed by an Avi tag (Avitag?).
The protein has a calculated MW of 143.5 kDa. The protein migrates as 150-170 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
標記（Labeling）
Biotinylation of this product is performed using Avitag? technology. Briefly, the single lysine residue in the Avitag is enzymatically labeled with biotin.
蛋白標記度（Protein Ratio）
Passed as determined by the HABA assay / binding ELISA.
內(nèi)毒素（Endotoxin）
Less than 1.0 EU per μg by the LAL method.
純度（Purity）
>95% as determined by SDS-PAGE.
制劑（Formulation）
Lyophilized from 0.22 μm filtered solution in PBS, pH7.4 with trehalose as protectant.
Contact us for customized product form or formulation.
重構(gòu)方法（Reconstitution）
Please see Certificate of Analysis for specific instructions.
For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.
存儲（Storage）
For long term storage, the product should be stored at lyophilized state at -20°C or lower.
Please avoid repeated freeze-thaw cycles.
This product is stable after storage at:
-20°C to -70°C for 12 months in lyophilized state;
-70°C for 3 months under sterile conditions after reconstitution.
背景（Background）
CD109是一種糖基磷脂酰肌醇（GPI）連接的糖蛋白，定位于血小板、活化T細胞和內(nèi)皮細胞的表面。CD109在許多惡性腫瘤中表達，包括各種鱗狀細胞癌和腺癌，并作為多功能輔助受體發(fā)揮作用。據(jù)報道，CD109與轉(zhuǎn)化生長因子（TGF）-β受體相關(guān)，并負調(diào)控角質(zhì)形成細胞中的TGF-β信號傳導。此外，CD109可能與信號轉(zhuǎn)導子和轉(zhuǎn)錄激活子-3信號傳導和異常細胞增殖有關(guān)。
關(guān)鍵字： CD109;CD109蛋白;CD109重組蛋白;ACRO;百普賽斯;
百普賽斯集團ACROBiosystems Group（股票代碼：301080）是成立于2010年的跨國生物科技公司，是為全球生物醫(yī)藥、健康產(chǎn)業(yè)領(lǐng)域提供關(guān)鍵生物試劑產(chǎn)品及解決方案的行業(yè)平臺型基石企業(yè)。2021年在創(chuàng)業(yè)板上市。百普賽斯集團業(yè)務遍布全球，橫跨亞洲、北美洲、歐洲，在中國、美國、瑞士等12個城市設(shè)有辦公室、研發(fā)中心及生產(chǎn)基地。目前累計服務客戶超6000家，與全球Top 20醫(yī)藥企業(yè)均建立了長期、穩(wěn)定的合作伙伴關(guān)系。集團旗下?lián)碛衅放艫CROBiosystems百普賽斯、bioSeedin柏思薈、Condense Capital墾拓資本和ACRODiagnostics百斯醫(yī)學等。