Human NPTX2 Protein, His Tag (MALS verified)
分子別名(Synonym)
Neuronal pentraxin II,NP-II,NPTX2
表達區(qū)間及表達系統(tǒng)(Source)
Human NPTX2, His Tag (NP2-H52H6) is expressed from human 293 cells (HEK293). It contains AA Gly 16 - Leu 431 (Accession # P47972).
蛋白結構(Molecular Characterization)
This protein carries a polyhistidine tag at the C-terminus.
The protein has a calculated MW of 47.7 kDa. The protein migrates as 50-63 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
內毒素(Endotoxin)
Less than 1.0 EU per μg by the LAL method.
純度(Purity)
>95% as determined by SDS-PAGE.
制劑(Formulation)
Lyophilized from 0.22 μm filtered solution in PBS, pH7.4 with trehalose as protectant.
Contact us for customized product form or formulation.
重構方法(Reconstitution)
Please see Certificate of Analysis for specific instructions.
For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.
存儲(Storage)
For long term storage, the product should be stored at lyophilized state at -20°C or lower.
Please avoid repeated freeze-thaw cycles.
This product is stable after storage at:
-20°C to -70°C for 12 months in lyophilized state;
-70°C for 3 months under sterile conditions after reconstitution.
背景(Background)
神經元五聚蛋白2(NPTX2),也稱為神經元活動調節(jié)五聚蛋白,是一種分泌型糖蛋白,其特征是環(huán)狀多聚體結構。在體內,NTPX2通過與跨膜蛋白神經元筆曲毒素受體(NPTXR)結合發(fā)揮各種神經作用。NPTX2被認為在傳遞神經遞質和維持突觸可塑性方面起著至關重要的作用。它還參與了α-氨基-3-羥基-5-甲基-4-異惡唑丙酸(AMPA)型谷氨酸受體在已建立的突觸上的聚集,導致多巴胺能神經細胞的非凋亡細胞死亡。帕金森?。?/span>PD)組織中該基因的上調表明該蛋白可能參與PD的病理過程。
關鍵字: NPTX2;NPTX2蛋白;NP-II;ACRO;百普賽斯;
百普賽斯集團ACROBiosystems Group(股票代碼:301080)是成立于2010年的跨國生物科技公司,是為全球生物醫(yī)藥、健康產業(yè)領域提供關鍵生物試劑產品及解決方案的行業(yè)平臺型基石企業(yè)。2021年在創(chuàng)業(yè)板上市。百普賽斯集團業(yè)務遍布全球,橫跨亞洲、北美洲、歐洲,在中國、美國、瑞士等12個城市設有辦公室、研發(fā)中心及生產基地。目前累計服務客戶超6000家,與全球Top 20醫(yī)藥企業(yè)均建立了長期、穩(wěn)定的合作伙伴關系。集團旗下?lián)碛衅放艫CROBiosystems百普賽斯、bioSeedin柏思薈、Condense Capital墾拓資本和ACRODiagnostics百斯醫(yī)學等。