Human Nogo Receptor / NgR Protein, His Tag (SPR verified)
分子別名(Synonym)
Reticulon-4 receptor,Nogo-66 receptor
表達區(qū)間及表達系統(tǒng)(Source)
Human Nogo Receptor, His Tag (NOR-H52H3) is expressed from human 293 cells (HEK293). It contains AA Cys 27 - Ser 447 (Accession # Q9BZR6).
Predicted N-terminus: Cys 27
蛋白結(jié)構(gòu)(Molecular Characterization)
This protein carries a polyhistidine tag at the C-terminus.
The protein has a calculated MW of 47.2 kDa. The protein migrates as 63-70 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
內(nèi)毒素(Endotoxin)
Less than 1.0 EU per μg by the LAL method.
純度(Purity)
>90% as determined by SDS-PAGE.
制劑(Formulation)
Lyophilized from 0.22 μm filtered solution in PBS, pH7.4 with trehalose as protectant.
Contact us for customized product form or formulation.
重構(gòu)方法(Reconstitution)
Please see Certificate of Analysis for specific instructions.
For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.
存儲(Storage)
For long term storage, the product should be stored at lyophilized state at -20°C or lower.
Please avoid repeated freeze-thaw cycles.
This product is stable after storage at:
-20°C to -70°C for 12 months in lyophilized state;
-70°C for 3 months under sterile conditions after reconstitution.
背景(Background)
Nogo受體/網(wǎng)織紅蛋白-4受體在調(diào)節(jié)成人中樞神經(jīng)系統(tǒng)的軸突再生和神經(jīng)元可塑性中起著重要作用。在出生后的大腦發(fā)育中發(fā)揮作用。軸突在大腦中線的正常遷移和胼胝體的正常形成所必需的。保護運動神經(jīng)元免于凋亡;抗凋亡的保護作用可能是通過與MAG的相互作用介導的。在皮質(zhì)發(fā)育過程中,與RTN4和LINGO1協(xié)同作用,調(diào)節(jié)神經(jīng)元前體細胞的運動。與其他家庭成員一樣,它在限制大腦發(fā)育過程中形成的樹突棘數(shù)量和突觸數(shù)量方面發(fā)揮著作用。
關(guān)鍵字: Nogo Receptor;Nogo Receptor蛋白;Nogo受體;ACRO;百普賽斯;
百普賽斯集團ACROBiosystems Group(股票代碼:301080)是成立于2010年的跨國生物科技公司,是為全球生物醫(yī)藥、健康產(chǎn)業(yè)領(lǐng)域提供關(guān)鍵生物試劑產(chǎn)品及解決方案的行業(yè)平臺型基石企業(yè)。2021年在創(chuàng)業(yè)板上市。百普賽斯集團業(yè)務遍布全球,橫跨亞洲、北美洲、歐洲,在中國、美國、瑞士等12個城市設(shè)有辦公室、研發(fā)中心及生產(chǎn)基地。目前累計服務客戶超6000家,與全球Top 20醫(yī)藥企業(yè)均建立了長期、穩(wěn)定的合作伙伴關(guān)系。集團旗下?lián)碛衅放艫CROBiosystems百普賽斯、bioSeedin柏思薈、Condense Capital墾拓資本和ACRODiagnostics百斯醫(yī)學等。