Human GAD1 / GAD67 Protein, His Tag
分子別名(Synonym)
GAD1,GAD67,Glutamate decarboxylase 1
表達區(qū)間及表達系統(tǒng)(Source)
Human GAD1, His Tag (GA1-H5543) is expressed from Baculovirus-Insect cells. It contains AA Met 1 - Leu 594 (Accession # Q99259-1).
Predicted N-terminus: Met 1
蛋白結構(Molecular Characterization)
This protein carries a polyhistidine tag at the N-terminus
The protein has a calculated MW of 68.8 kDa. The protein migrates as 66 kDa, 90 kDa and >116 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
內毒素(Endotoxin)
Less than 1.0 EU per μg by the LAL method.
純度(Purity)
>85% as determined by SDS-PAGE.
制劑(Formulation)
Supplied as 0.2 μm filtered solution in 20 mM Tris, 500 mM Nacl, pH8.5 with glycerol as protectant.
Contact us for customized product form or formulation.
運輸(Shipping)
This product is supplied and shipped with dry ice, please inquire the shipping cost.
存儲(Storage)
Please avoid repeated freeze-thaw cycles.
This product is stable after storage at:
The product MUST be stored at -70°C or lower upon receipt;
-70°C for 3 months under sterile conditions.
背景(Background)
谷氨酸脫羧酶(GAD)是一種催化谷氨酸脫羧為γ氨基丁酸(GABA)的酶,γ氨基丁酸是高級腦區(qū)的主要抑制性遞質,也是胰島中推測的旁分泌激素。GAD使用磷酸吡哆醛(PLP)作為輔因子。GAD的兩種分子形式(65 kDa和67 kDa)高度保守,均在中樞神經(jīng)系統(tǒng)、胰島細胞、睪丸、輸卵管和卵巢中表達。這些異構體在大鼠和小鼠的大腦中呈區(qū)域性細胞質分布。GAD65是一種ampiphilic,膜錨定蛋白(585 a.a.),負責囊泡GABA的產(chǎn)生。GAD67是細胞質(594 a.a.),似乎負責大量的細胞質GABA產(chǎn)生。
關鍵字: GAD1;GAD1蛋白;GAD67蛋白;ACRO;百普賽斯;
百普賽斯集團ACROBiosystems Group(股票代碼:301080)是成立于2010年的跨國生物科技公司,是為全球生物醫(yī)藥、健康產(chǎn)業(yè)領域提供關鍵生物試劑產(chǎn)品及解決方案的行業(yè)平臺型基石企業(yè)。2021年在創(chuàng)業(yè)板上市。百普賽斯集團業(yè)務遍布全球,橫跨亞洲、北美洲、歐洲,在中國、美國、瑞士等12個城市設有辦公室、研發(fā)中心及生產(chǎn)基地。目前累計服務客戶超6000家,與全球Top 20醫(yī)藥企業(yè)均建立了長期、穩(wěn)定的合作伙伴關系。集團旗下?lián)碛衅放艫CROBiosystems百普賽斯、bioSeedin柏思薈、Condense Capital墾拓資本和ACRODiagnostics百斯醫(yī)學等。