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Cantrixil,Cantrixil
  • Cantrixil,Cantrixil

Cantrixil|T39586|TargetMol

價(jià)格 ￥3930
包裝 2mg
最小起訂量 1mg
發(fā)貨地 上海
更新日期 2024-12-12
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產(chǎn)品詳情

中文名稱:Cantrixil英文名稱:Cantrixil
CAS:2135511-22-5品牌: TargetMol
產(chǎn)地: 美國(guó)保存條件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
產(chǎn)品類別: 抑制劑
貨號(hào): T39586
2024-12-12 Cantrixil Cantrixil 2mg/3930RMB 3930 TargetMol 美國(guó) Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. 抑制劑

Product Introduction

Bioactivity

名稱Cantrixil
描述Cantrixil (TRX-E-002-1) is a second-generation super-benzopyran (SBP) compound, derived from TRX-E-002. It elicits an increase in phosphorylated c-Jun levels, leading to caspase-mediated apoptosis in ovarian cancer cells. Cantrixil exhibits potent pan anti-cancer activity against various cancer phenotypes.
體外活性TRX-E-002-1 shows broad cytotoxic activity against ovarian, prostate and lung cancer cells, with IC 50 values of ≤0.1 μM (SK-OV-3, JAM, OVCAR-3 cells: IC 50 =0.023-0.065 μM; DU145, PC3; C4-2B cells: IC 50 =0.014-0.096 μM; A549 cells: IC 50 =0.058 μM). Activity in pancreatic and colorectal cancer cells and glioblastoma cells are more variable[1]. Cantrixil (0.2 μM; 2-24 hours) shows high levels of phosphorylated c-Jun (p-c-Jun) and low levels of phosphorylated-ERK (p-ERK)[2]. Cantrixil (2.45 μM; 2-24 hours) induces a significant increase in both caspase-3/7 and caspase-9 activity at 16 and 24 hours[2]. TRX-E-002-1 inhibits multiple cytochrome P450 drug-metabolizing enzymes, including CYP2C9, CYP2C8, CYP2C19, CYP2B6, CYP3A4, CYP2D6, CYP2A6 and CYP1A2. IC 50 values ranges from 1.5 to 75 μM (612-30,600 ng/mL)[1]. Western Blot Analysis[2]Cell Line: Ovarian cancer stem cells (OCSCs) Concentration: 0.2 μM Incubation Time: 2, 4, 8, 16, 24 hours Result: Showed higher levels of phosphorylated c-Jun (p-c-Jun) and lower levels of phosphorylated-ERK (p-ERK). Showed a time-dependent increase in p-c-Jun accompanied by a time-dependent increase in total c-Jun.
體內(nèi)活性TRX-E-002-1 (100 mg/kg/day; IP; for 13-14 days) significantly inhibits tumour growth in disseminated ovarian cancer mouse model[1]. TRX-E-002-1 (100 mg/kg/day; IP; for 4 weeks) inhibits tumour growth and reduces terminal tumour burden by 77% in the recurrent ovarian cancer mouse model[1]. TRX-E-002-1 (100 mg/kg/day; IP; for 18 days) significantly reduces terminal pancreatic tumour burden in a mouse model of pancreatic cancer (human Panc-1 pancreatic tumour cells implanted orthotopically into female NOD-SCID mice)[1]. TRX-E-002-1 (100 mg/kg; IP) has a T 1/2 of 2.5 hours, a C max of 8355 ng/mL and an AUC 0-∞ of 40600 ng?h/mL[1]. Animal Model: Disseminated ovarian cancer mouse model[1]Dosage: 100 mg/kg (dissolved in 20% SBECD) Administration: IP; once daily; for 13-14 days Result: Significantly inhibited tumour growth and reduced excised tumour weight at termination by 50-72%. Animal Model: Male female Sprague-Dawley rats[1]Dosage: 100 mg/kg (Pharmacokinetic Analysis) Administration: IP Result: Had a T 1/2 of 2.5 hours, a C max of 8355 ng/mL and an AUC 0-∞ of 40600 ng?h/mL.
存儲(chǔ)條件Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
關(guān)鍵字Cantrixil
關(guān)鍵字： TRX-E-002-1|TargetMol

公司簡(jiǎn)介

TargetMol Chemicals Inc. 總部位于馬薩諸塞州波士頓，致力于為全球生化領(lǐng)域科學(xué)家的研究提供專業(yè)的產(chǎn)品和服務(wù)。TargetMol?品牌的客戶群分布于40多個(gè)國(guó)家和地區(qū)，已發(fā)展成為全球知名的化合物庫(kù)和小分子化合物研究供應(yīng)商。 TargetMol?可提供160多種滿足不同需求的化合物庫(kù)，以及多種類型的生化試劑產(chǎn)品，包括12000多種抑制劑、16000多種天然產(chǎn)物和各類多肽、抗體、生命科學(xué)試劑盒等，此外，我們還建設(shè)有CADD（計(jì)算機(jī)輔助藥物設(shè)計(jì)）研究中心、藥理實(shí)驗(yàn)室、藥化合成平臺(tái)三大技術(shù)中心，全方位滿足客戶的定制需求。 憑借我們優(yōu)質(zhì)的產(chǎn)品和服務(wù)、快速高效的全球供應(yīng)鏈和專業(yè)的技術(shù)支持，我們將有效幫助您縮短研發(fā)周期，取得更成功的結(jié)果。
成立日期 2013-04-18 （12年） 注冊(cè)資本 566.265100萬(wàn)人民幣
員工人數(shù) 100-500人 年?duì)I業(yè)額 ￥ 1億以上
主營(yíng)行業(yè) 天然產(chǎn)物,生化試劑,分子生物學(xué),分子砌塊,生物技術(shù)服務(wù) 經(jīng)營(yíng)模式 貿(mào)易,工廠,試劑,定制,服務(wù)
  • TargetMol中國(guó)（陶術(shù)生物）
VIP 3年
  • 公司成立：12年
  • 注冊(cè)資本：566.265100萬(wàn)人民幣
  • 企業(yè)類型：有限責(zé)任公司(自然人投資或控股)
  • 主營(yíng)產(chǎn)品：小分子抑制劑、藥物篩選化合物庫(kù)、藥物篩選等
  • 公司地址：靜安區(qū)江場(chǎng)三路238號(hào)8樓
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