化合物 SF1670|T6667|TargetMol

價(jià)格	￥348	￥491	￥828
包裝	1mg	2mg	5mg

最小起訂量	1mg
發(fā)貨地	上海
更新日期	2024-12-12

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產(chǎn)品詳情

中文名稱:化合物 SF1670	英文名稱:SF1670
CAS:345630-40-2	品牌: TargetMol
產(chǎn)地: 美國(guó)	保存條件: Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice.
純度規(guī)格: 98.54%	產(chǎn)品類別: 抑制劑
貨號(hào): T6667

Product Introduction

Bioactivity

名稱	SF1670
描述	SF1670 (PTPase CD45 Inhibitor) is a specific PTEN inhibitor with IC50 of 2 μM.
細(xì)胞實(shí)驗(yàn)	Cells are plated into 96-well plates in RPMI 1640 medium supplemented with 10% FBS and incubated overnight at 37°C. in an incubator containing an atmosphere of 5% CO2. The following day, the medium is replaced and cells are starved by placing in 100 uL of serum-free medium for 3 hours. Serially diluted test compounds are added to the wells and incubated with the cells for 2 hours at 37°C. Compounds are tested in a range from 1 mM to 0.1 nM depending on solubility. MTT is added to the wells at a final concentration of 5 μg/ml and incubated with the cells for 3 more hours. At the end of the incubation, the medium is aspirated and the MTT stain in the cells is dissolved by the addition of 100 μL DMSO. Optical density of each well is then measured at 570 nm using a SpectroMax Plus spectrophotometric plate reader. The IC50 determination from the data was made using Prism software.(Only for Reference)
激酶實(shí)驗(yàn)	PTEN Inhibition Assay: To determine the dose response of potential PTEN inhibitors, doses of test compounds ranging from 1 nM to 250 uM (final reaction mix concentrations) are evaluated in the general PTEN inhibition assay. To obtain performed IC50 data, two separate rounds of the dose response assay are performed. In the first round, PTEN activity is tested in the presence of inhibitor at 10 fold serial dilutions ranging from 1 nM to 250 uM. Once the concentration range is determined, at which PTEN activity changes dramatically, two additional concentration data points within this range are added and the PTEN inhibition assay is then rerun for the second round. The PTEN inhibition IC50 is presented as the inhibitor concentration at which 50% of the PTEN activity. When the assay was run on multiple occasions and gave slightly different IC50 then those are reported as a range of IC50 found.
體外活性	SF1670在HBEC、PC-3、H1299細(xì)胞中表現(xiàn)出強(qiáng)烈的細(xì)胞毒性，其半抑制濃度(IC50)分別為5 μM、10 μM和44 μM。在小鼠主動(dòng)脈環(huán)Matrigel血管生成模型中，SF1670促進(jìn)血管生成過(guò)程。[1] SF1670增強(qiáng)中性粒細(xì)胞對(duì)趨化因子誘導(dǎo)的PtdIns(3,4,5)P3信號(hào)傳導(dǎo)，提高中性粒細(xì)胞功能。[2]
體內(nèi)活性	SF1670 (500 nM i.v.)的預(yù)處理能增強(qiáng)中性粒細(xì)胞減少癥小鼠在腹膜炎和細(xì)菌性肺炎中的細(xì)菌殺傷能力，并降低與中性粒細(xì)胞減少相關(guān)的肺炎死亡率。[2]
存儲(chǔ)條件	Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice.
溶解度	DMSO : 30.7 mg/mL (100 mM)
關(guān)鍵字	SF1670 \| SF 1670 \| inhibit \| Autophagy \| MMAC1 \| Inhibitor \| Phosphatase and tensin homolog \| SF-1670 \| Phosphatase \| PTEN
相關(guān)產(chǎn)品	Guanidine hydrochloride \| Naringin \| Stearic acid \| Valproic Acid \| Taurine \| Gefitinib \| Aceglutamide \| Hydroxychloroquine \| Curcumin \| Stavudine \| Paeonol \| Sodium 4-phenylbutyrate
相關(guān)庫(kù)	抑制劑庫(kù) \| 經(jīng)典已知活性庫(kù) \| 抗癌化合物庫(kù) \| 已知活性化合物庫(kù) \| 抗癌細(xì)胞代謝庫(kù) \| 自噬庫(kù) \| 抗衰老化合物庫(kù) \| 抗肝癌化合物庫(kù) \| 抗氧化化合物庫(kù) \| PI3K/Akt/mTOR 化合物庫(kù)

關(guān)鍵字： PTPase CD45 Inhibitor|||PTP CD45 Inhibitor|TargetMol

公司簡(jiǎn)介

TargetMol Chemicals Inc. 總部位于馬薩諸塞州波士頓，致力于為全球生化領(lǐng)域科學(xué)家的研究提供專業(yè)的產(chǎn)品和服務(wù)。TargetMol?品牌的客戶群分布于40多個(gè)國(guó)家和地區(qū)，已發(fā)展成為全球知名的化合物庫(kù)和小分子化合物研究供應(yīng)商。 TargetMol?可提供160多種滿足不同需求的化合物庫(kù)，以及多種類型的生化試劑產(chǎn)品，包括12000多種抑制劑、16000多種天然產(chǎn)物和各類多肽、抗體、生命科學(xué)試劑盒等，此外，我們還建設(shè)有CADD（計(jì)算機(jī)輔助藥物設(shè)計(jì)）研究中心、藥理實(shí)驗(yàn)室、藥化合成平臺(tái)三大技術(shù)中心，全方位滿足客戶的定制需求。憑借我們優(yōu)質(zhì)的產(chǎn)品和服務(wù)、快速高效的全球供應(yīng)鏈和專業(yè)的技術(shù)支持，我們將有效幫助您縮短研發(fā)周期，取得更成功的結(jié)果。

成立日期	2013-04-18 （12年）	注冊(cè)資本	566.265100萬(wàn)人民幣
員工人數(shù)	100-500人	年?duì)I業(yè)額	￥ 1億以上
主營(yíng)行業(yè)	天然產(chǎn)物,生化試劑,分子生物學(xué),分子砌塊,生物技術(shù)服務(wù)	經(jīng)營(yíng)模式	貿(mào)易,工廠,試劑,定制,服務(wù)

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公司成立：12年
注冊(cè)資本：566.265100萬(wàn)人民幣
企業(yè)類型：有限責(zé)任公司(自然人投資或控股)
主營(yíng)產(chǎn)品：小分子抑制劑、藥物篩選化合物庫(kù)、藥物篩選等
公司地址：靜安區(qū)江場(chǎng)三路238號(hào)8樓

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