靛玉紅-3' -單肟|T5200|TargetMol

價格	￥186	￥413	￥662
包裝	1mg	5mg	10mg

最小起訂量	1mg
發(fā)貨地	上海
更新日期	2024-12-12

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產(chǎn)品詳情

中文名稱:靛玉紅-3' -單肟	英文名稱:Indirubin-3'-monoxime
CAS:160807-49-8	品牌: TargetMol
產(chǎn)地: 美國	保存條件: Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice.
純度規(guī)格: 99.65%	產(chǎn)品類別: 抑制劑
貨號: T5200

Product Introduction

Bioactivity

名稱	Indirubin-3'-monoxime
描述	Indirubin-3'-monoxime (Indirubin-3'-oxime) is a potent inhibitor of GSK3β (IC50: 22 nM) and also inhibits CDKs ( (IC50s: 100/180/250 nM for Cdk5/p35, Cdk1/cyclin B, Cdk2/cyclin E).
細(xì)胞實(shí)驗(yàn)	To determine the effects of aminopurvalanol and indirubin-3′-monoxime on tau phosphorylation, Sf9 cells infected with baculovirus expressing htau23 protein were treated 36 h post-infection (when cells have already expressed levels of tau sufficient for the outgrowth of cell processes) with 20 μM inhibitors for 3 h before being harvested [1].
激酶實(shí)驗(yàn)	Kinase activities were assayed in Buffer A or C (unless otherwise stated), at 30?°C, at a final ATP concentration of 15 μM. Blank values were subtracted, and activities were calculated as picomoles of phosphate incorporated for a 10-min incubation. The activities are usually expressed in percentage of the maximal activity, i.e. in the absence of inhibitors. Controls were performed with appropriate dilutions of dimethyl sulfoxide. In a few cases, phosphorylation of the substrate was assessed by autoradiography after SDS-PAGE [1].
動物實(shí)驗(yàn)	Male mice (5–6 weeks old) were randomly assigned into five groups (n = 10). Group 1: received normal pellet diet (NPD); Group 2: received a HFD; Group 3–5 received HFD for 8 weeks followed by Indirubin-3'-monoxime (IMX) treatment (0.1, 0.2 and 0.4 mg/kg i.p, respectively) once daily for 1 week. IMX was dissolved in (2.5% v/v) DMSO in saline. The mice in NPD and HFD groups received an equivalent volume of vehicle (2.5% v/v DMSO in saline). The composition of HFD was similar as described by Srinivasan. Doses of IMX were selected based on the reports available in literature. Mice were kept under standard husbandry conditions (22 ± 1 C and 60% humidity) and maintained on a 12/12-h light/dark schedule with free access to food and water for 8 weeks. Body weight was recorded weekly throughout the experimental period [4].
體外活性	Indirubins是強(qiáng)效的GSK-3 beta抑制劑（IC50：5-50 nM）。通過GSK-3β，細(xì)菌表達(dá)的重組人tau蛋白確實(shí)在體外被磷酸化，且這種磷酸化作用可被Indirubin-3'-monoxime 以劑量依賴的方式抑制，IC50值約為100 nM [1]。Indirubin-3'-monoxime可可逆性地在G2期阻滯異步HBL-100細(xì)胞。它抑制了共識CDK磷酸化位點(diǎn)以及在特定CDK1/cyclin B磷酸化位點(diǎn)上的核仁蛋白的磷酸化 [2]。在基于細(xì)胞和無細(xì)胞的實(shí)驗(yàn)中，Indirubin-3'-monoxime選擇性地抑制了5-脂氧合酶（5-LO），這是LT生物合成中的關(guān)鍵酶，其IC50值處于低μM范圍內(nèi) [3]。
體內(nèi)活性	經(jīng)IMX處理的小鼠，在血漿中的葡萄糖、甘油三酯、膽固醇、胰島素水平方面顯示出顯著下降，并在學(xué)習(xí)記憶能力上表現(xiàn)出改善；同時減輕了氧化應(yīng)激和AChE活性。此外，IMX還能劑量依賴性地提高高脂飲食（HFD）喂養(yǎng)小鼠大腦中的胰島素和BDNF水平[4]。
存儲條件	Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice.
溶解度	H2O : Insoluble Ethanol : 15 mg/mL DMSO : 55 mg/mL (198.36 mM)
關(guān)鍵字	Indirubin 3' monoxime \| Lipoxygenase \| GSK-3 \| LOX \| inhibit \| Indirubin3'monoxime \| Inhibitor \| CDK \| Glycogen synthase kinase-3 \| Glycogen synthase kinase 3 \| Indirubin-3'-monoxime \| Cyclin dependent kinase
相關(guān)產(chǎn)品	Sodium Oxamate \| 5-LOX inhibitor \| 5-Aminosalicylic Acid \| 4-Chloro-2'-bromoacetophenone \| Ribociclib \| Resveratrol \| CASIN \| Caffeic Acid \| CHIR-99021 \| Abemaciclib \| Malotilate \| NNK
相關(guān)庫	抑制劑庫 \| 神經(jīng)保護(hù)化合物庫 \| 經(jīng)典已知活性庫 \| 已知活性化合物庫 \| 抗癌細(xì)胞代謝庫 \| 細(xì)胞周期化合物庫 \| 激酶抑制劑庫 \| 抗衰老化合物庫 \| 抗氧化化合物庫 \| 神經(jīng)退行性疾病化合物庫

關(guān)鍵字：靛玉紅-3' -單肟|||Indirubin-3'-oxime|TargetMol

公司簡介

TargetMol Chemicals Inc. 總部位于馬薩諸塞州波士頓，致力于為全球生化領(lǐng)域科學(xué)家的研究提供專業(yè)的產(chǎn)品和服務(wù)。TargetMol?品牌的客戶群分布于40多個國家和地區(qū)，已發(fā)展成為全球知名的化合物庫和小分子化合物研究供應(yīng)商。 TargetMol?可提供160多種滿足不同需求的化合物庫，以及多種類型的生化試劑產(chǎn)品，包括12000多種抑制劑、16000多種天然產(chǎn)物和各類多肽、抗體、生命科學(xué)試劑盒等，此外，我們還建設(shè)有CADD（計算機(jī)輔助藥物設(shè)計）研究中心、藥理實(shí)驗(yàn)室、藥化合成平臺三大技術(shù)中心，全方位滿足客戶的定制需求。憑借我們優(yōu)質(zhì)的產(chǎn)品和服務(wù)、快速高效的全球供應(yīng)鏈和專業(yè)的技術(shù)支持，我們將有效幫助您縮短研發(fā)周期，取得更成功的結(jié)果。

成立日期	2013-04-18 （12年）	注冊資本	566.265100萬人民幣
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公司成立：12年
注冊資本：566.265100萬人民幣
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