化合物 CCT128930|T6303|TargetMol

價格	￥213	￥473	￥773
包裝	1mg	5mg	10mg

最小起訂量	1mg
發(fā)貨地	上海
更新日期	2024-12-12

QQ交談微信洽談

產品詳情

中文名稱:化合物 CCT128930	英文名稱:CCT128930
CAS:885499-61-6	品牌: TargetMol
產地: 美國	保存條件: Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice.
純度規(guī)格: 99.18%	產品類別: 抑制劑
貨號: T6303

Product Introduction

Bioactivity

Name	CCT128930
Description	CCT128930 is a potent, ATP-competitive and selective inhibitor of Akt2 with IC50 of 6 nM, 28-fold greater selectivity for Akt2 than the closely related PKA kinase.
Cell Research	Cells are seeded in 96-well plates and allowed to attach for 36 hours to ensure exponential growth prior to treatment. In vitro antiproliferative activity is determined using a 96-hour SRB assay. TCA-fixed cells are stained for 30 minutes with 0.4% (wt/vol) SRB dissolved in 1% acetic acid. At the end of the staining period, SRB is removed and cultures are quickly rinsed four times with 1% acetic acid to remove unbound dye. The acetic acid is poured directly into the culture wells from a beaker. This procedure permits rinsing to be performed quickly so that desorption of protein-bound dye does not occur. Residual wash solution is removed by sharply flicking plates over a sink, which ensures the complete removal of rinsing solution. Because of the strong capillary action in 96-well plates, draining by gravity alone often fails to remove the rinse solution when plates are simply inverted. After being rinsed, the cultures are air dried until no standing moisture is visible. Bound dye is solubilized with 10 mM unbuffered Tris base (pH 10.5) for 5 minutes on a gyratory shaker. OD is read in either a UVmax microtiter plate reader or a Beckman DU-70 spectrophotometer. For maximum sensitivity, OD is measured at 564 nm. Because readings are linear with dye concentrations only below 1.8 OD units, however, suboptimal wavelengths are generally used, so that all samples in an experiment remains within the linear OD range. With most cell lines, wavelengths of approximately 490-530 nm works well for this purpose.(Only for Reference)
Kinase Assay	Kinase assays: Profiling against 50 different human kinases is carried out using 10 μM CCT128930 at an ATP concentration equivalent to the Km for each enzyme.
In vitro	CCT128930 exhibits marked antiproliferative activity against PTEN-deficient human tumor cell lines including U87 mg human glioblastoma cells, LNCaP human prostate cancer cells and PC3 human prostate cancer cells with GI50 of 6.3 μM, 0.35 μM and 1.9 μM, respectively. Furthermore, CCT128930 causes a G1 arrest in PTEN-null U87 mg human glioblastoma cells and Akt pathway blockade. [1]
In vivo	CCT128930 at 25 mg/kg i.p. shows a marked antitumor effect in established PTEN-null U87 mg human glioblastoma xenografts with a treated:control (T/C) ratio of 48% on day 12. In HER2-positive, PIK3CA-mutant BT474 human breast cancer xenografts, CCT128930 at 40 mg/kg also produces a profound antitumor effect with complete growth arrest and a T/C ratio of 29% on day 22. CCT128930 administrated via i.v. reaches a peak concentration of 6.4 μM in plasma and is eliminated with a relatively short half-life, high volume of distribution, and rapid clearance, giving an area under the curve AUC0-∞ of 4.6 μM h. CCT128930 administrated via i.p. leads to the peak plasma drug concentration of 1.3 μM and the corresponding AUC0-∞ of 1.3 μM·h. Oral CCT128930 administration leads to the peak plasma concentration of only 0.43 μM and a correspondingly low AUC0-∞ of 0.4 μM·h. [1]
Storage	Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice.
Solubility Information	Ethanol : 6 mg/mL (17.55 mM) H2O : <1 mg/mL DMSO : 25 mg/mL (73.13 mM)
Keywords	growth \| Autophagy \| Protein kinase B \| phosphorylation \| breast cancer \| inhibit \| arrest \| selective \| DNA \| PKB \| Apoptosis \| glioblastoma \| BT474 \| cell \| cycle \| CCT-128930 \| Akt \| PTEN \| Inhibitor \| U87MG \| damage \| CCT 128930 \| CCT128930
Inhibitors Related	Oxyresveratrol \| Guanidine hydrochloride \| Naringin \| Taurine \| Gefitinib \| Xylitol \| Hydroxychloroquine \| Curcumin \| Stavudine \| Myricetin \| Paeonol \| Sodium 4-phenylbutyrate
Related Compound Libraries	Oxidation-Reduction Compound Library \| Neural Regeneration Compound Library \| HIF-1 Signaling Pathway Compound Library \| Glutamine Metabolism Compound Library \| PI3K-AKT-mTOR Compound Library \| Reprogramming Compound Library

關鍵字： CCT128930|TargetMol

公司簡介

TargetMol Chemicals Inc. 總部位于馬薩諸塞州波士頓，致力于為全球生化領域科學家的研究提供專業(yè)的產品和服務。TargetMol?品牌的客戶群分布于40多個國家和地區(qū)，已發(fā)展成為全球知名的化合物庫和小分子化合物研究供應商。 TargetMol?可提供160多種滿足不同需求的化合物庫，以及多種類型的生化試劑產品，包括12000多種抑制劑、16000多種天然產物和各類多肽、抗體、生命科學試劑盒等，此外，我們還建設有CADD（計算機輔助藥物設計）研究中心、藥理實驗室、藥化合成平臺三大技術中心，全方位滿足客戶的定制需求。憑借我們優(yōu)質的產品和服務、快速高效的全球供應鏈和專業(yè)的技術支持，我們將有效幫助您縮短研發(fā)周期，取得更成功的結果。

成立日期	2013-04-18 （12年）	注冊資本	566.265100萬人民幣
員工人數(shù)	100-500人	年營業(yè)額	￥ 1億以上
主營行業(yè)	天然產物,生化試劑,分子生物學,分子砌塊,生物技術服務	經營模式	貿易,工廠,試劑,定制,服務

TargetMol中國（陶術生物）

VIP 3年

公司成立：12年
注冊資本：566.265100萬人民幣
企業(yè)類型：有限責任公司(自然人投資或控股)
主營產品：小分子抑制劑、藥物篩選化合物庫、藥物篩選等
公司地址：靜安區(qū)江場三路238號8樓

進入店鋪

詢盤

店內推薦

萊鮑迪甙I|T13860|TargetMol

￥5690

化合物 Zidovudine glucuronide|T71983|TargetMol

￥13800

化合物 BI-4924|T14564|TargetMol

詢價

化合物 CCT128930|T6303|TargetMol相關廠家報價

產品名稱	價格		公司名稱	報價日期
CCT128930	詢價	VIP3年	陜西締都新材料有限公司	2024-12-18
aladdin 阿拉丁 C127073 CCT128930,AKT2 抑制劑 885499-61-6 98%	￥1823.90	VIP1年	上海阿拉丁生化科技股份有限公司	2024-11-29
aladdin 阿拉丁 C409110 CCT128930 885499-61-6 10mM in DMSO	￥1845.90	VIP13年	上海阿拉丁生化科技股份有限公司	2024-10-31
CCT128930	詢價		南京百鑫德諾生物科技有限公司	2024-09-26
(AKT抑制劑) CCT128930	詢價		南京百鑫德諾生物科技有限公司	2024-09-26

內容聲明:
以上所展示的信息由商家自行提供，內容的真實性、準確性和合法性由發(fā)布商家負責。商家發(fā)布價格指該商品的參考價格，并非原價，該價格可能隨著市場變化，或是由于您購買數(shù)量不同或所選規(guī)格不同而發(fā)生變化。最終成交價格，請咨詢商家，以實際成交價格為準。請意識到互聯(lián)網交易中的風險是客觀存在的