Human Integrin alpha L beta 2 (ITGAL&ITGB2) Heterodimer Protein, His Tag&Tag Free
分子別名（Synonym）
Integrin alpha L beta 2,ITGAL&ITGB2
表達(dá)區(qū)間及表達(dá)系統(tǒng)（Source）
Human ITGAL&ITGB2 Heterodimer Protein, His Tag&Tag Free (IT2-H53W3) is expressed from CHO cells. It contains AA Tyr 26 - Met 1089 (ITGAL) & Gln 23 - Asn 700 (ITGB2) (Accession # P20701-1 (ITGAL) & P05107-1 (ITGB2)).
Predicted N-terminus: Tyr 26 (ITGAL) & Gln 23 (ITGB2)
蛋白結(jié)構(gòu)（Molecular Characterization）
Human ITGAL&ITGB2 Heterodimer Protein, His Tag&Tag Free, produced by co-expression of ITGAL and ITGB2, has a calculated MW of 124.1 kDa (ITGAL) & 80.2 kDa (ITGB2). Subunit ITGAL is fused with an acidic tail at the C-terminus and followed by a polyhistidine tag and subunit ITGB2 contains no tag but a basic tail at the C-terminus. The protein migrates as 140-150 kDa (ITGAL) and 90-95 kDa (ITGB2) under non-reducing (NR) condition (SDS-PAGE) due to glycosylation.
內(nèi)毒素（Endotoxin）
Less than 1.0 EU per μg by the LAL method.
純度（Purity）
>95% as determined by SDS-PAGE.
制劑（Formulation）
Lyophilized from 0.22 μm filtered solution in 50 mM Tris, 150 mM NaCl, pH7.5 with trehalose as protectant.
Contact us for customized product form or formulation.
重構(gòu)方法（Reconstitution）
Please see Certificate of Analysis for specific instructions.
For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.
存儲(chǔ)（Storage）
For long term storage, the product should be stored at lyophilized state at -20°C or lower.
Please avoid repeated freeze-thaw cycles.
This product is stable after storage at:
-20°C to -70°C for 12 months in lyophilized state;
-70°C for 3 months under sterile conditions after reconstitution.
背景（Background）
整合素α-Lβ-2是ICAM1、ICAM2、ICAM3和ICAM4的受體。整合素αLβ2也是F11R的受體（通過相似性）。參與多種免疫現(xiàn)象，包括白細(xì)胞-內(nèi)皮細(xì)胞相互作用、細(xì)胞毒性T細(xì)胞介導(dǎo)的殺傷以及粒細(xì)胞和單核細(xì)胞的抗體依賴性殺傷。有助于自然殺傷細(xì)胞的細(xì)胞毒性。參與白細(xì)胞粘附和白細(xì)胞（包括T細(xì)胞和中性粒細(xì)胞）的遷移。骨髓中常見淋巴祖細(xì)胞的產(chǎn)生所必需的，表明其在淋巴生成中的作用。整合素αLβ2與ICAM3相關(guān)，有助于巨噬細(xì)胞吞噬凋亡的中性粒細(xì)胞。
關(guān)鍵字： 整合素αLβ2;Integrin αLβ2;αLβ2;ACRO;百普賽斯;
百普賽斯集團(tuán)ACROBiosystems Group（股票代碼：301080）是成立于2010年的跨國(guó)生物科技公司，是為全球生物醫(yī)藥、健康產(chǎn)業(yè)領(lǐng)域提供關(guān)鍵生物試劑產(chǎn)品及解決方案的行業(yè)平臺(tái)型基石企業(yè)。2021年在創(chuàng)業(yè)板上市。百普賽斯集團(tuán)業(yè)務(wù)遍布全球，橫跨亞洲、北美洲、歐洲，在中國(guó)、美國(guó)、瑞士等12個(gè)城市設(shè)有辦公室、研發(fā)中心及生產(chǎn)基地。目前累計(jì)服務(wù)客戶超6000家，與全球Top 20醫(yī)藥企業(yè)均建立了長(zhǎng)期、穩(wěn)定的合作伙伴關(guān)系。集團(tuán)旗下?lián)碛衅放艫CROBiosystems百普賽斯、bioSeedin柏思薈、Condense Capital墾拓資本和ACRODiagnostics百斯醫(yī)學(xué)等。