Human B7-H7 / HHLA2 Protein, His Tag (MALS verified)
分子別名(Synonym)
B7-H7,HHLA2,B7 Homolog 7
表達區(qū)間及表達系統(tǒng)(Source)
Human B7-H7, His Tag (B77-H52H6) is expressed from human 293 cells (HEK293). It contains AA Ile 23 - Asn 344 (Accession # Q9UM44-1).
蛋白結(jié)構(gòu)(Molecular Characterization)
This protein carries a polyhistidine tag at the C-terminus.
The protein has a calculated MW of 39.0 kDa. The protein migrates as 50-66 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE) due to glycosylation.
內(nèi)毒素(Endotoxin)
Less than 1.0 EU per μg by the LAL method.
純度(Purity)
>95% as determined by SDS-PAGE.
>90% as determined by SEC-MALS.
制劑(Formulation)
Lyophilized from 0.22 μm filtered solution in PBS, pH7.4 with trehalose as protectant.
Contact us for customized product form or formulation.
重構(gòu)方法(Reconstitution)
Please see Certificate of Analysis for specific instructions.
For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.
存儲(Storage)
For long term storage, the product should be stored at lyophilized state at -20°C or lower.
Please avoid repeated freeze-thaw cycles.
This product is stable after storage at:
-20°C to -70°C for 12 months in lyophilized state;
-70°C for 3 months under sterile conditions after reconstitution.
背景(Background)
B7-H7(HHLA2)是新發(fā)現(xiàn)的調(diào)節(jié)人類T細胞功能的B7家族成員。B7-H7以前被稱為人內(nèi)源性逆轉(zhuǎn)錄病毒-H長末端重復(fù)結(jié)合2(HHLA2),功能不明。最近,B7-H7已被確定為人類CD28H的特異性配體。在TCR信號存在的情況下,B7-H7-CD28H通路通過AKT依賴性信號級聯(lián)強烈促進CD4+T細胞增殖和細胞因子產(chǎn)生,表明B7-H7包含一種新的共刺激通路。B7-H7的第一個IgV結(jié)構(gòu)域可能與一個假定的受體結(jié)合,與其他B7家族成員顯示出最高的同源性。
關(guān)鍵字: B7-H7;B7-H7蛋白;B7-H7重組蛋白;ACRO;百普賽斯;
百普賽斯集團ACROBiosystems Group(股票代碼:301080)是成立于2010年的跨國生物科技公司,是為全球生物醫(yī)藥、健康產(chǎn)業(yè)領(lǐng)域提供關(guān)鍵生物試劑產(chǎn)品及解決方案的行業(yè)平臺型基石企業(yè)。2021年在創(chuàng)業(yè)板上市。百普賽斯集團業(yè)務(wù)遍布全球,橫跨亞洲、北美洲、歐洲,在中國、美國、瑞士等12個城市設(shè)有辦公室、研發(fā)中心及生產(chǎn)基地。目前累計服務(wù)客戶超6000家,與全球Top 20醫(yī)藥企業(yè)均建立了長期、穩(wěn)定的合作伙伴關(guān)系。集團旗下?lián)碛衅放艫CROBiosystems百普賽斯、bioSeedin柏思薈、Condense Capital墾拓資本和ACRODiagnostics百斯醫(yī)學(xué)等。