鼠尾草酸|T4957|TargetMol

價(jià)格	￥269	￥391	￥773
包裝	5mg	10mg	25mg

最小起訂量	1mg
發(fā)貨地	上海
更新日期	2024-12-02

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產(chǎn)品詳情

中文名稱:鼠尾草酸	英文名稱:Carnosic acid
CAS:3650-09-7	品牌: TargetMol
產(chǎn)地: 美國(guó)	保存條件: keep away from direct sunlight,keep away from moisture \| Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice.
純度規(guī)格: 99.5%	產(chǎn)品類別: 抑制劑
貨號(hào): T4957

Product Introduction

Bioactivity

名稱	Carnosic acid
描述	Carnosic acid is a lipid absorption inhibitor, endowed with antioxidative, antimicrobial, photoprotective potential, and antiproliferative properties.
細(xì)胞實(shí)驗(yàn)	Human dopaminergic neuroblastoma SH-SY5Y cells were cultured in Dulbecco's modified Eagle's medium (DMEM)/F-12 HAM nutrient medium (1:1 mixture; supplemented with 10% fetal bovine serum (FBS), 2 mM L-glutamine, penicillin (1000 units/mL), streptomycin (1000 μg/mL), and amphotericin B (2.5 μg/mL)) in a 5% CO2 humidified incubator at 37 °C. SH-SY5Y cells were cultured until a confluence of 80–90% was achieved and then trypsinized. H2O2 was utilized at 300 μM for different periods of incubation according to each specific assay. A pretreatment with CA (dissolved in DMSO) at 1 μM for 12 h was performed in order to test the ability of this diterpene in preventing the deleterious effects triggered by H2O2 in SH-SY5Y cells [2].
動(dòng)物實(shí)驗(yàn)	Male C57BL/KsJ-db/db mice were given an intradermal injection of 100 μg of chicken type II collagen emulsified in complete Freund's adjuvant (1:1, w/v) into the base of the tail. 18 days after primary immunization, all mice showed signs of arthritis, and a booster, which consisted of 100 μg of chicken type II collagen emulsified in incomplete Freund's adjuvant (IFA; 1:1, v/v), was injected intradermally. All mice were divided into 7 groups; normal (Nor), db/db, db/db/CIA, and db/db/CIA with CA treatment. To investigate the effects of Carnosic acid (CA) on the development of arthritis, db/db mice and db/db/CIA mice were treated with 30 mg/kg body weight CA (CAL) and 60 mg/kg body weight CA (CAH) seven times per week for 4 weeks intraperitoneally after the booster injection. CA was prepared as 10 mmol/L stock solutions in DMSO [3].
體外活性	ARPE-19細(xì)胞先用10 μM的Carnosic acid預(yù)處理24小時(shí)，然后用丙烯酰胺（0.7或1 mM）處理24小時(shí)。與僅用丙烯酰胺處理的ARPE-19細(xì)胞相比，先用10 μMCarnosic acid預(yù)處理的ARPE-19細(xì)胞顯示出明顯增加的細(xì)胞活力和降低的細(xì)胞死亡率[1]。人類神經(jīng)母細(xì)胞瘤SH-SY5Y細(xì)胞用1 μM的Carnosic acid預(yù)處理12小時(shí)，可防止過(guò)氧化氫（H2O2）引起的TCA酶（異檸檬酸酶、α-酮戊二酸脫氫酶（α-KGDH）、琥珀酸脫氫酶（SDH））功能受損，并消除了復(fù)合體I和V的抑制，并通過(guò)與Nrf2相關(guān)的機(jī)制恢復(fù)了ATP水平[2]。
體內(nèi)活性	肉豆蔻酸顯著下調(diào)空腹血糖水平、口服葡萄糖耐量試驗(yàn)(OGTT)和胰島素耐量試驗(yàn)(ITT)中的葡萄糖水平，改善了CIA誘導(dǎo)的骨質(zhì)流失，并在CIA誘導(dǎo)的db/db小鼠關(guān)節(jié)炎模型中減少了促炎細(xì)胞因子和活性氧(ROS)的生成[3]。
存儲(chǔ)條件	keep away from direct sunlight,keep away from moisture \| Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice.
溶解度	DMSO : 100 mg/mL (300.82 mM) H2O : Insoluble
關(guān)鍵字	Inhibitor \| inhibit \| Carnosic acid \| Bacterial \| Apoptosis
相關(guān)產(chǎn)品	L-Glutamic acid \| Dehydroacetic acid sodium \| Doxycycline \| Methyl anthranilate \| Neomycin sulfate \| Dimethyl sulfoxide \| Dextran sulfate sodium salt (MW 4500-5500) \| Stavudine \| Ampicillin sodium \| Sulfamethoxazole sodium \| Kanamycin sulfate \| Sodium 4-phenylbutyrate
相關(guān)庫(kù)	抑制劑庫(kù) \| 經(jīng)典已知活性庫(kù) \| 植物來(lái)源化合物庫(kù) \| 中藥單體化合物庫(kù) \| 天然產(chǎn)物庫(kù) \| 神經(jīng)退行性疾病化合物庫(kù) \| 免疫/炎癥分子化合物庫(kù) \| 萜類天然產(chǎn)物庫(kù) \| 中藥抗炎分子庫(kù) \| 高通量篩選天然產(chǎn)物庫(kù) \| 天然多酚類化合物庫(kù) \| 抗感染天然產(chǎn)物庫(kù)

關(guān)鍵字：鼠尾草酸|TargetMol

公司簡(jiǎn)介

上海陶術(shù)生物科技有限公司為美國(guó)Target Molecule Corp. ( Target Mol ) 在上海建立的全資子公司。我們與美國(guó)波士頓、德國(guó)慕尼黑的同事一起，為北美、歐洲和亞洲從事藥物研發(fā)和生物學(xué)研究的科學(xué)家提供優(yōu)質(zhì)的產(chǎn)品和專業(yè)的服務(wù)。公司下設(shè)篩選事業(yè)部，化學(xué)事業(yè)部，生物事業(yè)部和新材料部。從虛擬篩選到實(shí)體化合物分子供應(yīng)；從商業(yè)化產(chǎn)品銷售到個(gè)性化定制合成；從對(duì)明確靶點(diǎn)的分子篩選到對(duì)明確分子的多靶點(diǎn)篩選，從高通量篩選到化學(xué)結(jié)構(gòu)優(yōu)化，我們都可以滿足您的科研用品及技術(shù)服務(wù)的需求。經(jīng)過(guò)在中國(guó)市場(chǎng)五年的精心耕耘，我們已成為篩選化合物領(lǐng)域優(yōu)秀的供應(yīng)商，為超過(guò)五百家學(xué)校和各類企業(yè)提供了品質(zhì)卓越的小分子化合物和藥物篩

成立日期	2013-04-18 （12年）	注冊(cè)資本	566.2651萬(wàn)人民幣
員工人數(shù)	100-500人	年?duì)I業(yè)額	￥ 1億以上
主營(yíng)行業(yè)	化學(xué)試劑,生物活性小分子	經(jīng)營(yíng)模式	貿(mào)易,試劑,定制,服務(wù)

TargetMol中國(guó)（陶術(shù)生物）

VIP 12年

公司成立：12年
注冊(cè)資本：566.2651萬(wàn)人民幣
企業(yè)類型：有限責(zé)任公司(自然人投資或控股)
主營(yíng)產(chǎn)品：小分子抑制劑，藥物篩選化合物庫(kù)，天然產(chǎn)物，活性分子化合物等
公司地址：上海市閘北區(qū)江場(chǎng)三路28號(hào)4樓

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