Monoclonal Anti-Human CD3 Antibody, Mouse IgG2a (Clone: OKT3), premium grade (CHO)
抗體來源（Source）
Monoclonal Anti-Human CD3 Antibody, Mouse IgG2a (Clone: OKT3), premium grade (CDE-CH44G1) is recombinantly produced from CHO cells.
該產(chǎn)品是在我們嚴格的質(zhì)量控制體系下生產(chǎn)的，該體系包含一套全面的測試，包括無菌和內(nèi)毒素測試。在早期臨床前階段，產(chǎn)品性能經(jīng)過仔細驗證和測試，以確保其與細胞培養(yǎng)用途或任何其他應用的兼容性。當準備過渡到后期臨床階段時，我們還提供定制的GMP蛋白質(zhì)服務，以滿足您的需求。我們將與您合作，根據(jù)您的要求定制和開發(fā)GMP級產(chǎn)品，該產(chǎn)品也符合細胞療法細胞制造中使用的原材料和輔助材料的要求。
亞型（Isotype）
Mouse IgG2a/kappa
偶聯(lián)（Conjugate）
Unconjugated
特異性（Specificity）
This product is a specific antibody specifically reacts with CD3 epsilon.
內(nèi)毒素（Endotoxin）
Less than 0.002 EU per μg by the LAL method.
蛋白A殘留（Protein A）
<5 ppm of protein tested by ELISA.
宿主蛋白殘留（Host Cell Protein）
<0.5 ng/μg of protein tested by ELISA.
宿主核酸殘留（Host Cell DNA）
<0.02 ng/μg of protein tested by qPCR.
純度（Purity）
>95% as determined by SDS-PAGE.
>95% as determined by SEC-MALS.
制劑（Formulation）
Supplied as 0.2 μm filtered solution in PBS, pH7.4 with trehalose as protectant.
Contact us for customized product form or formulation.
運輸（Shipping）
This product is supplied and shipped with dry ice, please inquire the shipping cost.
存儲（Storage）
For long term storage, the product should be stored at liquid state at -70°C.
This product is stable after storage at:
2-8°C for 12 months under sterile condition;
-70°C for 24 months.
背景（Background）
CD3e molecule, epsilon is also known as CD3E, is a T-cell surface single-pass type I membrane glycoprotein. CD3E contains 1 Ig-like (immunoglobulin-like) domain and 1 ITAM domain. CD3E, together with CD3-gamma, CD3-delta and CD3-zeta, and the T-cell receptor alpha/beta and gamma/delta heterodimers, forms the T cell receptor-CD3 complex. This complex plays an important role in coupling antigen recognition to several intracellular signal-transduction pathways. The genes encoding the epsilon, gamma and delta polypeptides are located in the same cluster on chromosome 11. The epsilon polypeptide plays an essential role in T-cell development. CD3E plays an essential role in T-cell development, and defects in CD3E gene cause severe immunodeficiency. CD3E gene has also been linked to a susceptibility to type I diabetes in women. CD3E has been shown to interact with TOP2B, CD3EAP and NCK2.
關鍵字： CD3 Antibody;OKT3;OKT3抗體;ACRO;百普賽斯;
百普賽斯集團ACROBiosystems Group（股票代碼：301080）是成立于2010年的跨國生物科技公司，是為全球生物醫(yī)藥、健康產(chǎn)業(yè)領域提供關鍵生物試劑產(chǎn)品及解決方案的行業(yè)平臺型基石企業(yè)。2021年在創(chuàng)業(yè)板上市。百普賽斯集團業(yè)務遍布全球，橫跨亞洲、北美洲、歐洲，在中國、美國、瑞士等12個城市設有辦公室、研發(fā)中心及生產(chǎn)基地。目前累計服務客戶超6000家，與全球Top 20醫(yī)藥企業(yè)均建立了長期、穩(wěn)定的合作伙伴關系。集團旗下?lián)碛衅放艫CROBiosystems百普賽斯、bioSeedin柏思薈、Condense Capital墾拓資本和ACRODiagnostics百斯醫(yī)學等。