Mouse latent GDF-8 Protein, His Tag 

分子別名（Synonym）

latent GDF-8

表達(dá)區(qū)間及表達(dá)系統(tǒng)（Source）

Mouse latent GDF-8 Protein, His Tag (GD8-M5243) is expressed from human 293 cells (HEK293). It contains AA Asn 25 - Ser 376 (Accession # O08689).

Predicted N-terminus: His

蛋白結(jié)構(gòu)（Molecular Characterization）

This protein carries a polyhistidine tag at the N-terminus.

The protein has a calculated MW of 42.0 kDa. The protein migrates as 35 kDa and 45-50 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE) due to glycosylation.

內(nèi)毒素（Endotoxin）

Less than 1.0 EU per μg by the LAL method.

純度（Purity）

>90% as determined by SDS-PAGE.

制劑（Formulation）

Lyophilized from 0.22 μm filtered solution in PBS, pH7.4 with trehalose as protectant.

Contact us for customized product form or formulation.

重構(gòu)方法（Reconstitution）

Please see Certificate of Analysis for specific instructions.

For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

存儲(chǔ)（Storage）

For long term storage, the product should be stored at lyophilized state at -20°C or lower.

Please avoid repeated freeze-thaw cycles.

This product is stable after storage at:

-20°C to -70°C for 12 months in lyophilized state;

-70°C for 3 months under sterile conditions after reconstitution.

背景（Background）

生長(zhǎng)分化因子8（GDF8），也稱為肌肉生長(zhǎng)抑制素，是轉(zhuǎn)化生長(zhǎng)因子β超家族的獨(dú)特成員，在人類顆粒細(xì)胞中表達(dá)，在調(diào)節(jié)多種卵巢功能中起著重要作用。GDF8是骨骼肌生長(zhǎng)和分化的負(fù)調(diào)節(jié)因子。除了在肌肉骨骼系統(tǒng)中表達(dá)外，GDF8還在包括生殖系統(tǒng)在內(nèi)的各種組織中表達(dá)。