Mouse IL-17A / CTLA-8 Protein, His Tag (MALS verified)
分子別名(Synonym)
IL-17A,Interleukin-17A,CTLA-8,IL-17
表達區(qū)間及表達系統(tǒng)(Source)
Mouse IL-17A, His Tag (CT8-M5240) is expressed from human 293 cells (HEK293). It contains AA Ala 26 - Ala 158 (Accession # Q62386-1).
Predicted N-terminus: His
蛋白結(jié)構(gòu)(Molecular Characterization)
This protein carries a polyhistidine tag at the N-terminus.
The protein has a calculated MW of 15.8 kDa. The protein migrates as 18 kDa, 20-23 kDa, 26 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE) due to glycosylation.
內(nèi)毒素(Endotoxin)
Less than 1.0 EU per μg by the LAL method.
純度(Purity)
>90% as determined by SDS-PAGE.
制劑(Formulation)
Lyophilized from 0.22 μm filtered solution in PBS, pH7.4 with trehalose as protectant.
Contact us for customized product form or formulation.
重構(gòu)方法(Reconstitution)
Please see Certificate of Analysis for specific instructions.
For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.
存儲(Storage)
For long term storage, the product should be stored at lyophilized state at -20°C or lower.
Please avoid repeated freeze-thaw cycles.
This product is stable after storage at:
-20°C to -70°C for 12 months in lyophilized state;
-70°C for 3 months under sterile conditions after reconstitution.
背景(Background)
白細胞介素-17A(IL17A)也被稱為細胞毒性T淋巴細胞相關抗原8(CTLA8),這是一種由活化的T細胞產(chǎn)生的促炎細胞因子。IL17A可以調(diào)節(jié)NF-κB和絲裂原活化蛋白激酶的活性。此外,IL17A可以刺激IL6和環(huán)氧化酶-2(PTGS2/COX-2)的表達,并增強一氧化氮(NO)的產(chǎn)生。此外,IL17A既有糖基化的形式,也有非糖基化形式。高水平的IL-17與幾種慢性炎癥性疾病有關,包括類風濕性關節(jié)炎、銀屑病和多發(fā)性硬化癥。
關鍵字: IL-17A;IL-17A蛋白;IL-17A重組蛋白;ACRO;百普賽斯;
百普賽斯集團ACROBiosystems Group(股票代碼:301080)是成立于2010年的跨國生物科技公司,是為全球生物醫(yī)藥、健康產(chǎn)業(yè)領域提供關鍵生物試劑產(chǎn)品及解決方案的行業(yè)平臺型基石企業(yè)。2021年在創(chuàng)業(yè)板上市。百普賽斯集團業(yè)務遍布全球,橫跨亞洲、北美洲、歐洲,在中國、美國、瑞士等12個城市設有辦公室、研發(fā)中心及生產(chǎn)基地。目前累計服務客戶超6000家,與全球Top 20醫(yī)藥企業(yè)均建立了長期、穩(wěn)定的合作伙伴關系。集團旗下?lián)碛衅放艫CROBiosystems百普賽斯、bioSeedin柏思薈、Condense Capital墾拓資本和ACRODiagnostics百斯醫(yī)學等。