生物活性25-Hydroxycholesterol是膽固醇的代謝產(chǎn)物,由巨噬細(xì)胞響應(yīng)Toll樣受體(TLR)激活而產(chǎn)生和分泌。25-Hydroxycholesterol有效且選擇性抑制B細(xì)胞產(chǎn)生IgA,EC50約為65nM。靶點(diǎn)HumanEndogenousMetabolite體外研究Thesynthesisof25-hydroxycholesteroliscatalyzedbytheenzymecholesterol25-hydroxylase,whichusescholesterolandmolecularoxygenassubstratesandNADPHasacofactor.25-hydroxycholesterolisapotentbioactivelipidintheinnateandadaptiveimmunesystems.
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