| 名稱 | Glucagon (1-29), bovine, human, porcine |
| 描述 | Glucagon (1-29), bovine, human, porcine is a hormone produced by pancreatic α-cells with glucagon activity, which promotes glycogenolysis and gluconeogenesis, and is used in the study of obesity and diabetes. |
| 體外活性 | Glucagon (1-29), bovine, human, porcine 與其受體 Gcgr 結(jié)合后，激活 cAMP-PKA 信號通路，進(jìn)而促進(jìn)肝臟葡萄糖生成并引發(fā)高血糖癥。此外，Glucagon (1-29), bovine, human, porcine 還能刺激肝臟產(chǎn)生 kisspeptin1 和糖異生。[1]
Glucagon (1-29), bovine, human, porcine 在 100 nM 濃度下抑制人原代肝細(xì)胞中 CYP7A1 mRNA 的表達(dá)，并增加 HNF4α 的磷酸化水平。[3] |
| 體內(nèi)活性 | 低劑量的 20 μg/kg Glucagon (1-29), bovine, human, porcine 能夠升高血糖，但不會刺激在正常環(huán)境中喂養(yǎng)的小鼠分泌胰島素。與 PBS 對照相比，高劑量的 1 mg/kg Glucagon (1-29), bovine, human, porcine 可以降低血糖并刺激在正常環(huán)境中喂養(yǎng)的小鼠分泌胰島素。[4] |
| 存儲條件 | keep away from moisture,keep away from direct sunlight,store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| 溶解度 | DMSO : 1 mg/mL (0.29 mM), Sonication is recommended.
H2O : 4 mg/mL (1.15 mM), Adjust pH to 2 with HCl and sonication is recommended.)
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| 關(guān)鍵字 | 胰高血糖素 | Porcine glucagon | Glucagon , bovine, human, porcine | Glucagon (129), bovine, human, porcine | Glucagon (1 29), bovine, human, porcine | Glucagon |
| 相關(guān)產(chǎn)品 | HAEGTFTSDVS acetate | 6α-Methylprednisolone 21-hemisuccinate sodium salt | PF-06882961 | PF-06882961 Tris | Tirzepatide monosodium salt | LSN3318839 | Orforglipron | NNC 92-1687 | (S, R)-LSN 3318839 | Adomeglivant | Tirzepatide Acetate(2023788-19-2 free base) | Avexitide acetate |