S-甲基異硫脲半硫酸鹽|T22419

價(jià)格	￥256	￥413	￥588
包裝	10mg	25mg	50mg

最小起訂量	1mg
發(fā)貨地	上海
更新日期	2024-12-02

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產(chǎn)品詳情

中文名稱:S-甲基異硫脲半硫酸鹽	英文名稱:S-Methylisothiourea sulfate
CAS:867-44-7	品牌: TargetMol
產(chǎn)地: 美國(guó)	保存條件: Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice.
純度規(guī)格: 99.58%	產(chǎn)品類(lèi)別: 抑制劑
貨號(hào): T22419

Product Introduction

Bioactivity

名稱	S-Methylisothiourea sulfate
描述	S-Methylisothiourea sulfate ((S)-Methylisothiourea sulfate) is a potent and selective inhibitor of iNOS and exerts beneficial effects in rodent models of septic shock[1].
動(dòng)物實(shí)驗(yàn)	S-Methylisothiourea sulfate (Male Wistar rats (260-320 g); 0.01 mg/kg, 0.1 mg/kg, 1 mg/kg, 3 mg/kg; Intravenous injection) caused a prompt restoration of the blood pressure to pre-LPS levels at 3 mg/kg dose in LPS (10 mg/kg, i.v.)-treated rats and also inhibited iNOS activity measured in homogenates of lung[1].
體外活性	S-Methylisothiourea sulfate is a competitive inhibitor of iNOS activity at the L-arginine site. The effect of S-Methylisothiourea sulfate on iNOS activity can be reversed by excess L-arginine in a concentration-dependent manner. S-Methylisothiourea sulfate (up to 1 mM) does not inhibit the activity of xanthine oxidase, diaphorase, lactate dehydrogenase, monoamine oxidase, catalase, cytochrome P450, or superoxide dismutase. S-Methylisothiourea sulfate prevents the NO-mediated cytotoxic effect of LPS in cultured macrophages. S-Methylisothiourea sulfate (100 nM-100 μM) exhibits inhibitory effects on LPS (ug/mL)-induced nitrite production in J774.2 macrophages and rat aortic vascular smooth muscle cells[1].
體內(nèi)活性	S-Methylisothiourea sulfate dose-dependently reverses (0.01-3 mg/kg) the hypotension and the vascular hyporeactivity to vasoconstrictor agents caused by endotoxin [bacterial lipopolysaccharide (LPS), 10 mg/kg, i.v.] in anesthetized rats. Moreover, therapeutic administration of S-Methylisothiourea sulfate (5 mg/kg, i.p., given 2 hr after LPS, 10 mg/kg, i.p.) attenuates the rises in plasma alanine and aspartate aminotransferases, bilirubin, and creatinine and also prevents hypocalcaemia when measured 6 hr after administration of LPS. S-Methylisothiourea sulfate (1 mg/kg, i.p.) improves 24-hr survival of mice treated with a high dose of LPS (60 mg/kg, i.p.)[1].
存儲(chǔ)條件	Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice.
溶解度	H2O : 60 mg/mL (431.09 mM), Sonication is recommended. DMSO : < 1 mg/mL (insoluble or slightly soluble)
關(guān)鍵字	HSV \| septic \| S-Methylisothiourea \| blood \| NOS \| Methylisothiourea Sulfate \| S-Methylisothiourea Sulfate \| shock \| iNOS \| Nitric oxide synthases \| SMethylisothiourea sulfate \| Inhibitor \| Herpes simplex virus \| inhibit \| NO Synthase \| S Methylisothiourea sulfate \| hypotension \| pressure \| circulatory
相關(guān)產(chǎn)品	Oxyresveratrol \| Acyclovir \| Adenosine 5'-monophosphate monohydrate \| Diallyl disulfide \| Levamisole hydrochloride \| Mifepristone \| Dexamethasone acetate \| Methylene Blue trihydrate \| Ethyl cinnamate \| Idoxuridine \| L-Arginine \| L-NAME hydrochloride
相關(guān)庫(kù)	神經(jīng)保護(hù)化合物庫(kù) \| 抑制劑庫(kù) \| 經(jīng)典已知活性庫(kù) \| 已知活性化合物庫(kù) \| 抗感染化合物庫(kù) \| 抗衰老化合物庫(kù) \| 抗病毒庫(kù)

關(guān)鍵字： S-甲基異硫脲硫酸鹽|||S-甲基異硫脲半硫酸鹽|||(S)-Methylisothiourea sulfate|TargetMol

公司簡(jiǎn)介

上海陶術(shù)生物科技有限公司為美國(guó)Target Molecule Corp. ( Target Mol ) 在上海建立的全資子公司。我們與美國(guó)波士頓、德國(guó)慕尼黑的同事一起，為北美、歐洲和亞洲從事藥物研發(fā)和生物學(xué)研究的科學(xué)家提供優(yōu)質(zhì)的產(chǎn)品和專業(yè)的服務(wù)。公司下設(shè)篩選事業(yè)部，化學(xué)事業(yè)部，生物事業(yè)部和新材料部。從虛擬篩選到實(shí)體化合物分子供應(yīng)；從商業(yè)化產(chǎn)品銷(xiāo)售到個(gè)性化定制合成；從對(duì)明確靶點(diǎn)的分子篩選到對(duì)明確分子的多靶點(diǎn)篩選，從高通量篩選到化學(xué)結(jié)構(gòu)優(yōu)化，我們都可以滿足您的科研用品及技術(shù)服務(wù)的需求。經(jīng)過(guò)在中國(guó)市場(chǎng)五年的精心耕耘，我們已成為篩選化合物領(lǐng)域優(yōu)秀的供應(yīng)商，為超過(guò)五百家學(xué)校和各類(lèi)企業(yè)提供了品質(zhì)卓越的小分子化合物和藥物篩

成立日期	2013-04-18 （12年）	注冊(cè)資本	566.2651萬(wàn)人民幣
員工人數(shù)	100-500人	年?duì)I業(yè)額	￥ 1億以上
主營(yíng)行業(yè)	化學(xué)試劑,生物活性小分子	經(jīng)營(yíng)模式	貿(mào)易,試劑,定制,服務(wù)

TargetMol中國(guó)（陶術(shù)生物）

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公司成立：12年
注冊(cè)資本：566.2651萬(wàn)人民幣
企業(yè)類(lèi)型：有限責(zé)任公司(自然人投資或控股)
主營(yíng)產(chǎn)品：小分子抑制劑，藥物篩選化合物庫(kù)，天然產(chǎn)物，活性分子化合物等
公司地址：上海市閘北區(qū)江場(chǎng)三路28號(hào)4樓

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