Human CD98 Protein, His Tag (MALS verified)
分子別名(Synonym)
SLC3A2,CD98,4F2,4F2HC,4T2HC,CD98HC,MDU1,NACAE
表達區(qū)間及表達系統(tǒng)(Source)
Human CD98, His Tag (CD8-H5247) is expressed from human 293 cells (HEK293). It contains AA Arg 206 - Ala 630 (Accession # AAH01061).
Predicted N-terminus: His
蛋白結構(Molecular Characterization)
This protein carries a polyhistidine tag at the N-terminus.
The protein has a calculated MW of 47.7 kDa. The protein migrates as 55-66 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
內毒素(Endotoxin)
Less than 1.0 EU per μg by the LAL method.
純度(Purity)
>95% as determined by SDS-PAGE.
>90% as determined by SEC-MALS.
制劑(Formulation)
Lyophilized from 0.22 μm filtered solution in PBS, pH7.4 with trehalose as protectant.
Contact us for customized product form or formulation.
重構方法(Reconstitution)
Please see Certificate of Analysis for specific instructions.
For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.
存儲(Storage)
For long term storage, the product should be stored at lyophilized state at -20°C or lower.
Please avoid repeated freeze-thaw cycles.
This product is stable after storage at:
-20°C to -70°C for 12 months in lyophilized state;
-70°C for 3 months under sterile conditions after reconstitution.
背景(Background)
CD抗原CD98又稱4F2細胞表面抗原重鏈(4F2hc)、4F2重鏈抗原、溶質載體家族3成員2(SLC3A2)、淋巴細胞活化抗原4F2大亞基,是一種單程I型膜蛋白,屬于SLC3A轉運蛋白家族。SLC3A2/CD98在所有受試組織中普遍表達,在腎臟、胎盤和睪丸中檢測到最高水平,在胸腺中檢測到最低水平。SLC3A2/CD98是輕鏈氨基酸轉運蛋白功能所必需的,也參與苯丙氨酸、酪氨酸、亮氨酸、精氨酸和色氨酸等大中性氨基酸的非鈉依賴性、高親和力轉運。CD98參與引導和靶向LAT1和LAT2至質膜。當與SLC7A5或SLC7A8結合時,CD98通過跨膜立體選擇性運輸L-亞硝基半胱氨酸(L-CNSO)參與小分子量亞硝基硫醇的細胞活性。與ICAM1一起,通過產生和傳遞細胞內信號來調節(jié)極化腸細胞中的LAT2轉運活性。
關鍵字: CD98;CD98蛋白;CD98重組蛋白;ACRO;百普賽斯;
百普賽斯集團ACROBiosystems Group(股票代碼:301080)是成立于2010年的跨國生物科技公司,是為全球生物醫(yī)藥、健康產業(yè)領域提供關鍵生物試劑產品及解決方案的行業(yè)平臺型基石企業(yè)。2021年在創(chuàng)業(yè)板上市。百普賽斯集團業(yè)務遍布全球,橫跨亞洲、北美洲、歐洲,在中國、美國、瑞士等12個城市設有辦公室、研發(fā)中心及生產基地。目前累計服務客戶超6000家,與全球Top 20醫(yī)藥企業(yè)均建立了長期、穩(wěn)定的合作伙伴關系。集團旗下?lián)碛衅放艫CROBiosystems百普賽斯、bioSeedin柏思薈、Condense Capital墾拓資本和ACRODiagnostics百斯醫(yī)學等。