PE-Labeled Monoclonal Anti-G4S linker Antibody, Rabbit IgG (016) (0.03% Proclin)
抗體來源(Source)
Monoclonal Anti-G4S linker Antibody, Rabbit IgG (016) is a rabbit monoclonal antibody recombinantly expressed from human 293 cells (HEK293),which provides higher batch consistency and long term security of supply. It shows superior performance in flow cytometry assays with higher affinity and better specificity.
應用(Application)
Flow Cytometry (Evaluation of cell surface expressed CARs of varying specificity containing a G4S linker within the scFv of the extracellular domain).
克隆號(Clone)
016
種屬(Species)
Rabbit
亞型(Isotype)
Rabbit IgG | Rabbit Kappa
特異性(Specificity)
Specifically recognizes the scFv-based CARs containing a G4S linker.
偶聯(lián)(Conjugate)
PE
Excitation Wavelength: 488 nm / 561 nm
Emission Wavelength: 575 nm
推薦稀釋比(Recommended Dilution)
1:50
制劑(Formulation)
Lyophilized from 0.22 μm filtered solution in PBS, 0.03% Proclin 300, pH7.4, 0.2% BSA with trehalose as protectant.
Contact us for customized product form or formulation.
重構方法(Reconstitution)
Please see Certificate of Analysis for specific instructions.
For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.
存儲(Storage)
Please protect from light and avoid repeated freeze-thaw cycles.
This product is stable after storage at:
-20°C to -70°C for 24 months in lyophilized state;
-70°C for 12 months after reconstitution.
2-8°C for 12 months after reconstitution.
背景(Background)
G4S linker是單鏈抗體最常見的連接肽。它由重復序列(Gly-Gly-Gly-Gly-Ser)組成,通常在scFv片段中以15-mer(G4S)3或20-mer(G4S)4的形式存在。G4S linker已成為絕大多數(shù)CAR不可或缺的一部分,因為它連接scFvs的VH和VL識別結構域。G4S linker通常用于靶向實體瘤抗原(如HER2和CEA)的CAR,而惠特洛/218接頭肽主要用于靶向血液系統(tǒng)惡性腫瘤(如CD19 CAR產(chǎn)物)的CAR構建。
關鍵字: G4S linker;G4S linker抗體;Anti-G4S linker;ACRO;百普賽斯;
百普賽斯集團ACROBiosystems Group(股票代碼:301080)是成立于2010年的跨國生物科技公司,是為全球生物醫(yī)藥、健康產(chǎn)業(yè)領域提供關鍵生物試劑產(chǎn)品及解決方案的行業(yè)平臺型基石企業(yè)。2021年在創(chuàng)業(yè)板上市。百普賽斯集團業(yè)務遍布全球,橫跨亞洲、北美洲、歐洲,在中國、美國、瑞士等12個城市設有辦公室、研發(fā)中心及生產(chǎn)基地。目前累計服務客戶超6000家,與全球Top 20醫(yī)藥企業(yè)均建立了長期、穩(wěn)定的合作伙伴關系。集團旗下?lián)碛衅放艫CROBiosystems百普賽斯、bioSeedin柏思薈、Condense Capital墾拓資本和ACRODiagnostics百斯醫(yī)學等。