Human uPAR / PLAUR Protein, His Tag (MALS verified)

分子別名（Synonym）

uPAR,PLAUR,CD87,MO3

表達(dá)區(qū)間及表達(dá)系統(tǒng)（Source）

Human uPAR, His Tag (UPR-H5226) is expressed from human 293 cells (HEK293). It contains AA Leu 23 - Arg 303 (Accession # AAH02788).

Predicted N-terminus: Leu 23

蛋白結(jié)構(gòu)（Molecular Characterization）

This protein carries a polyhistidine tag at the C-terminus.

The protein has a calculated MW of 32.3 kDa. The protein migrates as 40-55 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE) due to glycosylation.

內(nèi)毒素（Endotoxin）

Less than 1.0 EU per μg by the LAL method.

純度（Purity）

>92% as determined by SDS-PAGE.

>90% as determined by SEC-MALS.

制劑（Formulation）

Lyophilized from 0.22 μm filtered solution in PBS, pH7.4 with trehalose as protectant.

Contact us for customized product form or formulation.

重構(gòu)方法（Reconstitution）

Please see Certificate of Analysis for specific instructions.

For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

存儲(chǔ)（Storage）

For long term storage, the product should be stored at lyophilized state at -20°C or lower.

Please avoid repeated freeze-thaw cycles.

This product is stable after storage at:

-20°C to -70°C for 12 months in lyophilized state;

-70°C for 3 months under sterile conditions after reconstitution.

背景（Background）

尿激酶纖溶酶原激活物表面受體（U-PAR）也稱為PLAUR、單核細(xì)胞激活抗原Mo3、CD抗原CD87。PLAUR包含三個(gè)UPAR/Ly6結(jié)構(gòu)域。U-PAR在大腦外側(cè)區(qū)的神經(jīng)元中表達(dá)（在蛋白質(zhì)水平上），也在大腦中表達(dá)。PLAUR/CD87與MRC2、SRPX2和SORL1相互作用。PLAUR/UPAR作為尿激酶型纖溶酶原激活物的受體，在定位和促進(jìn)纖溶酶形成方面發(fā)揮作用。U-PAR介導(dǎo)U-PA的蛋白水解非依賴性信號(hào)轉(zhuǎn)導(dǎo)激活效應(yīng)。