Human TDP-43 Protein, His Tag
分子別名(Synonym)
TAR DNA-binding protein 43
表達區(qū)間及表達系統(tǒng)(Source)
Human TDP-43, His Tag (TD3-H5145) is expressed from E. coli cells. It contains AA Met 1 - Met 414 (Accession # Q13148-1).
Predicted N-terminus: Met
蛋白結構(Molecular Characterization)
This protein carries a polyhistidine tag at the N-terminus.
The protein has a calculated MW of 46.8 kDa. The protein migrates as 54-56 kDa under reducing (R) condition (SDS-PAGE).
內毒素(Endotoxin)
Less than 1.0 EU per μg by the LAL method.
純度(Purity)
>90% as determined by SDS-PAGE.
制劑(Formulation)
Supplied as 0.2 μm filtered solution in 50 mM HEPES, 500 mM NaCl, 0.4 M Arginine, pH8.0 with glycerol as protectant.
Contact us for customized product form or formulation.
運輸(Shipping)
This product is supplied and shipped with dry ice, please inquire the shipping cost.
存儲(Storage)
Please avoid repeated freeze-thaw cycles.
This product is stable after storage at:
The product MUST be stored at -70°C or lower upon receipt;
-70°C for 12 months under sterile conditions.
背景(Background)
TDP-43是一種分子量為43KDa的反式反應(TAR)-D結合蛋白,由位于1號染色體上的TARDBP基因編碼。它是一種R/D結合蛋白,在結構上類似于典型的hnRNP蛋白家族成員。參與轉錄調控和R加工。它與散發(fā)性和家族性肌萎縮側索硬化癥和額顳葉變性有關。TDP-43主要是核的,但在病理條件下會轉移到細胞質中。TDP-43蛋白病的主要標志是細胞質積累、磷酸化、泛素化和截斷。
關鍵字: TDP-43;TDP-43蛋白;TDP-43重組蛋白;ACRO;百普賽斯;
百普賽斯集團ACROBiosystems Group(股票代碼:301080)是成立于2010年的跨國生物科技公司,是為全球生物醫(yī)藥、健康產業(yè)領域提供關鍵生物試劑產品及解決方案的行業(yè)平臺型基石企業(yè)。2021年在創(chuàng)業(yè)板上市。百普賽斯集團業(yè)務遍布全球,橫跨亞洲、北美洲、歐洲,在中國、美國、瑞士等12個城市設有辦公室、研發(fā)中心及生產基地。目前累計服務客戶超6000家,與全球Top 20醫(yī)藥企業(yè)均建立了長期、穩(wěn)定的合作伙伴關系。集團旗下擁有品牌ACROBiosystems百普賽斯、bioSeedin柏思薈、Condense Capital墾拓資本和ACRODiagnostics百斯醫(yī)學等。