Human IL-5 Protein, His Tag
分子別名(Synonym)
IL-5,TRF,IL5,Interleukin-5
表達區(qū)間及表達系統(tǒng)(Source)
Human IL-5 Protein, His Tag (IL5-H52H3) is expressed from human 293 cells (HEK293). It contains AA Ile 20 - Ser 134 (Accession # P05113-1).
Predicted N-terminus: His
蛋白結(jié)構(gòu)(Molecular Characterization)
This protein carries a polyhistidine tag at the N-terminus.
The protein has a calculated MW of 15.0 kDa. The protein migrates as 18-23 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
內(nèi)毒素(Endotoxin)
Less than 0.1 EU per μg by the LAL method.
無菌(Sterility)
Negative
支原體(Mycoplasma)
Negative.
純度(Purity)
>90% as determined by SDS-PAGE.
制劑(Formulation)
Lyophilized from 0.22 μm filtered solution in PBS, pH7.4 with trehalose as protectant.
Contact us for customized product form or formulation.
重構(gòu)方法(Reconstitution)
Please see Certificate of Analysis for specific instructions.
For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.
存儲(Storage)
For long term storage, the product should be stored at lyophilized state at -20°C or lower.
Please avoid repeated freeze-thaw cycles.
This product is stable after storage at:
-20°C to -70°C for 12 months in lyophilized state;
-70°C for 3 months under sterile conditions after reconstitution.
背景(Background)
白細胞介素5(IL-5)是由2型T輔助細胞和肥大細胞產(chǎn)生的白細胞介蛋白。IL-5是一種長115個氨基酸(在人類中為133個氨基酸)的TH2細胞因子,是造血家族的一部分。與該細胞因子家族的其他成員(即白細胞介素3和GM-CSF)不同,這種活性形式的糖蛋白是同二聚體。白細胞介素-5長期以來與包括過敏性鼻炎和哮喘在內(nèi)的幾種過敏性疾病的病因有關(guān),其中觀察到循環(huán)、氣道組織和誘導(dǎo)痰嗜酸性粒細胞的數(shù)量大幅增加。鑒于嗜酸性粒細胞的高度一致性,特別是過敏性哮喘的病理學,人們普遍推測嗜酸性粒血球在這種疾病的病理學中起著重要作用。靶向IL-5的藥物是美珠單抗和瑞珠單抗。
關(guān)鍵字: IL-5;IL-5蛋白;IL-5重組蛋白;ACRO;百普賽斯;
百普賽斯集團ACROBiosystems Group(股票代碼:301080)是成立于2010年的跨國生物科技公司,是為全球生物醫(yī)藥、健康產(chǎn)業(yè)領(lǐng)域提供關(guān)鍵生物試劑產(chǎn)品及解決方案的行業(yè)平臺型基石企業(yè)。2021年在創(chuàng)業(yè)板上市。百普賽斯集團業(yè)務(wù)遍布全球,橫跨亞洲、北美洲、歐洲,在中國、美國、瑞士等12個城市設(shè)有辦公室、研發(fā)中心及生產(chǎn)基地。目前累計服務(wù)客戶超6000家,與全球Top 20醫(yī)藥企業(yè)均建立了長期、穩(wěn)定的合作伙伴關(guān)系。集團旗下?lián)碛衅放艫CROBiosystems百普賽斯、bioSeedin柏思薈、Condense Capital墾拓資本和ACRODiagnostics百斯醫(yī)學等。