PE-Labeled Human CD5 Protein, His Tag (Site-specific conjugation)
分子別名（Synonym）
CD5,LEU1
表達區(qū)間及表達系統(tǒng)（Source）
PE-Labeled Human CD5, His Tag (CD5-HP2H6) is produced via site-specific conjugation of PE to Human CD5, His Tag under optimal conditions with a proprietary technology. Human CD5, His Tag is expressed from human 293 cells (HEK293). It contains AA Arg 25 - Pro 372 (Accession # P06127-1).
Predicted N-terminus: Arg 25
蛋白結構（Molecular Characterization）
This protein carries a polyhistidine tag at the C-terminus.
The protein has a calculated MW of 42.2 kDa.
應用說明（Application）
Evaluation of anti-CD5 CAR expression by flow cytometry. Please note that this product is NOT compatible to streptavidin detection system.
Conjugate
PE
Excitation Wavelength: 488 nm / 561 nm
Emission Wavelength: 575 nm
制劑（Formulation）
Lyophilized from 0.22 μm filtered solution in PBS, 0.5% BSA, pH7.4. Normally trehalose is added as protectant before lyophilization.
Contact us for customized product form or formulation.
重構方法（Reconstitution）
Please see Certificate of Analysis for specific instructions.
For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.
存儲（Storage）
For long term storage, the product should be stored at lyophilized state at -20°C or lower.
Please protect from light and avoid repeated freeze-thaw cycles.
This product is stable after storage at:
-20°C to -70°C for 12 months in lyophilized state;
-70°C for 3 months under sterile conditions after reconstitution.
背景（Background）
T細胞表面糖蛋白CD5也稱為淋巴細胞抗原T1/Leu-1和LEU1，在酪氨酸殘基上被LYN磷酸化，因此CD5可以為PTPN6/SHP-1創(chuàng)造結合位點。CD5可能作為調節(jié)T細胞增殖的受體。CD5在人類B細胞的不同發(fā)育和激活階段表達。CD5是TCR和BCR信號傳導的公認負調控因子。CD5陽性細胞還可以通過提供細胞因子如IL-10來預防自身免疫的出現(xiàn)。不同B和T細胞亞群的發(fā)育、選擇和功能或其優(yōu)先存活可能直接或間接依賴于與CD5或CD5樣分子相關的不同聚糖結構。
關鍵字： CD5;CD5蛋白;CD5重組蛋白;ACRO;百普賽斯;
百普賽斯集團ACROBiosystems Group（股票代碼：301080）是成立于2010年的跨國生物科技公司，是為全球生物醫(yī)藥、健康產業(yè)領域提供關鍵生物試劑產品及解決方案的行業(yè)平臺型基石企業(yè)。2021年在創(chuàng)業(yè)板上市。百普賽斯集團業(yè)務遍布全球，橫跨亞洲、北美洲、歐洲，在中國、美國、瑞士等12個城市設有辦公室、研發(fā)中心及生產基地。目前累計服務客戶超6000家，與全球Top 20醫(yī)藥企業(yè)均建立了長期、穩(wěn)定的合作伙伴關系。集團旗下?lián)碛衅放艫CROBiosystems百普賽斯、bioSeedin柏思薈、Condense Capital墾拓資本和ACRODiagnostics百斯醫(yī)學等。