Human MUC17 Protein, His Tag
分子別名（Synonym）
Mucin-17,MUC-17,MUC17,MUC-3,MUC3
表達區(qū)間及表達系統(tǒng)（Source）
Human MUC-17, His Tag (MU7-H52H3) is expressed from human 293 cells (HEK293). It contains AA Arg 4131 - Leu 4390 (Accession # Q685J3-1).
Predicted N-terminus: Arg 4131 & 4244 Ser
蛋白結構（Molecular Characterization）
This protein carries a polyhistidine tag at the C-terminus. This protein was cleaved within the SEA domain between 4243 Gly and 4244 Ser, and was cleaved into N and C-terminal fragment with calculated MW of 12.6 kDa and 18.6 kDa respectively. The protein migrates as 20 kDa and 25-35 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
內(nèi)毒素（Endotoxin）
Less than 1.0 EU per μg by the LAL method.
純度（Purity）
>90% as determined by SDS-PAGE.
制劑（Formulation）
Lyophilized from 0.22 μm filtered solution in PBS, pH7.4. Normally trehalose is added as protectant before lyophilization.
Contact us for customized product form or formulation.
重構方法（Reconstitution）
Please see Certificate of Analysis for specific instructions.
For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.
存儲（Storage）
For long term storage, the product should be stored at lyophilized state at -20°C or lower.
Please avoid repeated freeze-thaw cycles.
This product is stable after storage at:
-20°C to -70°C for 12 months in lyophilized state;
-70°C for 3 months under sterile conditions after reconstitution.
背景（Background）
膜粘蛋白在上皮細胞中具有多種功能，包括細胞保護、轉移過程中的外滲、維持管腔結構和信號轉導。MUC17包含一個延伸的、重復的細胞外糖基化結構域和一個羧基末端，羧基末端有兩個EGF樣結構域、一個SEA模塊結構域、另一個跨膜結構域和具有潛在絲氨酸和酪氨酸磷酸化位點的細胞質(zhì)結構域。通過其C末端與PDZK1相互作用，這種相互作用對于正確定位非常重要?？赡茉诰S持粘膜表面的穩(wěn)態(tài)方面發(fā)揮作用。
關鍵字： Mucin-17;MUC17蛋白;MUC17重組蛋白;ACRO;百普賽斯;
百普賽斯集團ACROBiosystems Group（股票代碼：301080）是成立于2010年的跨國生物科技公司，是為全球生物醫(yī)藥、健康產(chǎn)業(yè)領域提供關鍵生物試劑產(chǎn)品及解決方案的行業(yè)平臺型基石企業(yè)。2021年在創(chuàng)業(yè)板上市。百普賽斯集團業(yè)務遍布全球，橫跨亞洲、北美洲、歐洲，在中國、美國、瑞士等12個城市設有辦公室、研發(fā)中心及生產(chǎn)基地。目前累計服務客戶超6000家，與全球Top 20醫(yī)藥企業(yè)均建立了長期、穩(wěn)定的合作伙伴關系。集團旗下?lián)碛衅放艫CROBiosystems百普賽斯、bioSeedin柏思薈、Condense Capital墾拓資本和ACRODiagnostics百斯醫(yī)學等。