GDC-0310中間體3鹽酸鹽——用于合成GDC-0310的關(guān)鍵中間體。
GDC-0310 is a selective acyl-sulfonamide Nav1.7 inhibitor, with an IC50 of 0.6 nM for hNav1.7[1].
GDC-0310 exhibits an EC50 of 1.1 μM in vivo and a Ki of 1.8 nM for Nav1.7[1].
GDC-0310 shows substantially improved Nav selectivity and ADME properties[1].GDC-0310 exhibits t1/2 values of 5 h, 46 h and 4.4 h in rat (5 mg/kg, iv), dog (1 mg/kg, iv) and cynomolgus monkeys (2 mg/kg, iv), respectively
本溪市佳宜生物商貿(mào)有限公司
聯(lián)系商家時請?zhí)峒癱hemicalbook,有助于交易順利完成!
佳宜