Human CLEC4C / BDCA2 Protein, His Tag

分子別名（Synonym）

DLEC,CLEC4C,BDCA-2,CD303,CLECSF11,CLECSF7, HECL

表達(dá)區(qū)間及表達(dá)系統(tǒng)（Source）

Human CLEC4C, His Tag (CLC-H5245) is expressed from human 293 cells (HEK293). It contains AA Asn 45 - Ile 213 (Accession # Q8WTT0-1).

Predicted N-terminus: His

蛋白結(jié)構(gòu)（Molecular Characterization）

This protein carries a polyhistidine tag at the N-terminus.

The protein has a calculated MW of 26.6 kDa. The protein migrates as 33-40 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE) due to glycosylation.

內(nèi)毒素（Endotoxin）

Less than 1.0 EU per μg by the LAL method.

純度（Purity）

>90% as determined by SDS-PAGE.

制劑（Formulation）

Lyophilized from 0.22 μm filtered solution in PBS, pH7.4 with trehalose as protectant.

Contact us for customized product form or formulation.

重構(gòu)方法（Reconstitution）

Please see Certificate of Analysis for specific instructions.

For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

存儲(chǔ)（Storage）

For long term storage, the product should be stored at lyophilized state at -20°C or lower.

Please avoid repeated freeze-thaw cycles.

This product is stable after storage at:

-20°C to -70°C for 12 months in lyophilized state;

-70°C for 3 months under sterile conditions after reconstitution.

背景（Background）

CLEC4C（C型凝集素結(jié)構(gòu)域家族4成員C），也稱為BDCA2、CLECSF11、CLECSF7、DLEC和CD303。凝集素型細(xì)胞表面受體，可能在樹(shù)突狀細(xì)胞捕獲抗原中發(fā)揮作用。特異性識(shí)別含有三糖表位Gal（β1-3/4）GlcNAc（β1-2）Man的非唾液酸化半乳糖封端的雙十元聚糖。與血清IgG結(jié)合。有效地將配體靶向抗原處理室和肽裝載室，以呈遞給T細(xì)胞?？赡芙閷?dǎo)對(duì)漿細(xì)胞樣樹(shù)突狀細(xì)胞中IFN-α/β表達(dá)誘導(dǎo)的有效抑制。可能作為信號(hào)受體激活蛋白酪氨酸激酶并動(dòng)員細(xì)胞內(nèi)鈣。