TIM-4產(chǎn)品信息

別稱：TIM-4

物種：Human

屬性：Protein

標(biāo)記：Unconjugated

內(nèi)毒素（Endotoxin）

Less than 1.0 EU per μg by the LAL method.

純度（Purity）

>95% as determined by SDS-PAGE.

制劑（Formulation）

Lyophilized from 0.22 μm filtered solution in PBS, pH7.4 with trehalose as protectant.

Contact us for customized product form or formulation.

重構(gòu)方法（Reconstitution）

Please see Certificate of Analysis for specific instructions.

For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

存儲（Storage）

For long term storage, the product should be stored at lyophilized state at -20°C or lower.

Please avoid repeated freeze-thaw cycles.

This product is stable after storage at:

-20°C to -70°C for 12 months in lyophilized state;

-70°C for 3 months under sterile conditions after reconstitution.

TIM-4分子背景

T細(xì)胞免疫球蛋白粘蛋白（TIM）調(diào)節(jié)T細(xì)胞活化和耐受。清除凋亡細(xì)胞的一個重要步驟是識別吞噬細(xì)胞上的受體在凋亡細(xì)胞上暴露的磷脂酰絲氨酸（PS）。磷脂酰絲氨酸（PS）受體Tim-4通過與暴露在凋亡細(xì)胞表面的PS結(jié)合，介導(dǎo)凋亡細(xì)胞的吞噬作用，從而作為凋亡細(xì)胞的PS受體發(fā)揮作用。Tim-4直接結(jié)合PS并作為凋亡細(xì)胞吞噬的束縛受體，在過去十年中得到了廣泛的研究。然而，Tim-4在傳出細(xì)胞作用期間與其他吞噬受體協(xié)同作用的分子機(jī)制仍然難以捉摸。