FoxP3產(chǎn)品信息

別稱：FoxP3

物種：Human

屬性：Protein

標(biāo)記：Unconjugated

內(nèi)毒素（Endotoxin）

Less than 1.0 EU per μg by the LAL method.

純度（Purity）

>90% as determined by SDS-PAGE.

制劑（Formulation）

Lyophilized from 0.22 μm filtered solution in PBS, 0.5 M Arginine, pH7.4 with trehalose as protectant.

Contact us for customized product form or formulation.

重構(gòu)方法（Reconstitution）

Please see Certificate of Analysis for specific instructions.

For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

存儲(chǔ)（Storage）

For long term storage, the product should be stored at lyophilized state at -20°C or lower.

Please avoid repeated freeze-thaw cycles.

This product is stable after storage at:

-20°C to -70°C for 12 months in lyophilized state;

-70°C for 3 months under sterile conditions after reconstitution.

FoxP3分子背景

FOXP3是一種轉(zhuǎn)錄調(diào)節(jié)因子，對(duì)調(diào)節(jié)性T細(xì)胞（Treg）的發(fā)育和抑制功能至關(guān)重要。它通過(guò)允許獲得Treg譜系的完全抑制功能和穩(wěn)定性，以及通過(guò)直接調(diào)節(jié)常規(guī)T細(xì)胞的擴(kuò)增和功能，在維持免疫系統(tǒng)的穩(wěn)態(tài)方面發(fā)揮著至關(guān)重要的作用。根據(jù)其與其他轉(zhuǎn)錄因子、組蛋白乙?；负兔撘阴；傅南嗷プ饔?，可以作為轉(zhuǎn)錄抑制因子或轉(zhuǎn)錄激活因子。Treg的抑制活性涉及許多基因的協(xié)同激活，包括FOXP3對(duì)CTLA4和TNFRSF18的激活，以及對(duì)編碼細(xì)胞因子如白細(xì)胞介素-2（IL2）和干擾素γ（IFNG）的基因的抑制。該基因的缺陷是免疫缺陷性多內(nèi)分泌腺病、腸病、X連鎖綜合征（IPEX）的原因，也稱為X連鎖自身免疫免疫缺陷綜合征。