PDE10A

[1]. Kilburn JP, et al. N-Methylanilide and N-methylbenzamide derivatives as phosphodiesterase 10A (PDE10A) inhibitors. Bioorg Med Chem. 2013 Oct 1;21(19):6053-62.

[2]. Gate, E. N., et al. Structural studies on bioactive compounds. 4. A structure-antitumor activity study on analogs of N-methylformamide. Journal of Medicinal Chemistry, 1986, 29(6), 1046–1052.

貯存：

將密器密封，儲存密封的主藏器內(nèi)，并放在陰涼， 干爽的位置。

性質(zhì)與穩(wěn)定性：

常溫常壓下，或不分解產(chǎn)物。

五、分子性質(zhì)數(shù)據(jù)：

1、 摩爾折射率：39.87

2、 摩爾體積（m3/mol）：129.7

3、 等張比容（90.2K）：320.4

4、 表面張力（dyne/cm）：37.1

5、 極化率（10 -24cm 3）：15.80

1.疏水參數(shù)計算參考值（XlogP）:無

2.氫鍵供體數(shù)量:1

3.氫鍵受體數(shù)量:1

4.可旋轉(zhuǎn)化學鍵數(shù)量:1

5.互變異構(gòu)體數(shù)量:2

6.拓撲分子極性表面積29.1

7.重原子數(shù)量:10

8.表面電荷:0

9.復雜度:116

10.同位素原子數(shù)量:0

11.確定原子立構(gòu)中心數(shù)量:0

12.不確定原子立構(gòu)中心數(shù)量:0

13.確定化學鍵立構(gòu)中心數(shù)量:0

14.不確定化學鍵立構(gòu)中心數(shù)量:0

15.共價鍵單元數(shù)量:1

2. 沸點（oC,11 mmHg）： 167

Bioorg. Med. Chem. 21(19) , 6053-62, (2013)

PDE10A is a recently identified phosphodiesterase with a quite remarkable localization since the protein is abundant only in brain tissue. Based on this unique localization, research has focused exten...

J. Med. Chem. 29(5) , 600-6, (1986)

The electronic properties of orthopramides, a group of selective D-2 dopamine receptor antagonists, were investigated by calculating molecular electrostatic potentials (MEP) of model compounds with th...