EphA4產(chǎn)品信息
別稱:EphA4,HEK8,SEK,TYRO1,EK8
物種:Human
屬性:Protein
標(biāo)記:Unconjugated
內(nèi)毒素(Endotoxin)
Less than 1.0 EU per μg by the LAL method.
純度(Purity)
>95% as determined by SDS-PAGE.
制劑(Formulation)
Lyophilized from 0.22 μm filtered solution in PBS, pH7.4 with trehalose as protectant.
Contact us for customized product form or formulation.
重構(gòu)方法(Reconstitution)
Please see Certificate of Analysis for specific instructions.
For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.
存儲(chǔ)(Storage)
For long term storage, the product should be stored at lyophilized state at -20°C or lower.
Please avoid repeated freeze-thaw cycles.
This product is stable after storage at:
-20°C to -70°C for 12 months in lyophilized state;
-70°C for 3 months under sterile conditions after reconstitution.
EphA4分子背景
受體酪氨酸激酶與位于鄰近細(xì)胞上的膜結(jié)合的肝配蛋白-A家族配體混雜結(jié)合,導(dǎo)致接觸依賴性雙向信號(hào)傳導(dǎo)進(jìn)入鄰近細(xì)胞。受體下游的信號(hào)通路稱為正向信號(hào)通路,而肝配蛋白配體下游的信號(hào)途徑稱為反向信號(hào)通路。由配體ephrin-A1/EFNA1激活,調(diào)節(jié)細(xì)胞的遷移、整合素介導(dǎo)的粘附、增殖和分化。通過DSG1/橋粒糖蛋白-1和抑制ERK1/ERK2(分別為MAPK3/MAPK1)信號(hào)通路調(diào)節(jié)細(xì)胞粘附和分化。配體ephrin-A5/EFNA5的參與可能調(diào)節(jié)晶狀體纖維細(xì)胞的形狀和相互作用,對(duì)晶狀體透明度的發(fā)展和維持很重要。ephrin-A2/EFNA2可能通過調(diào)節(jié)破骨細(xì)胞生成和成骨細(xì)胞生成在骨重塑中發(fā)揮作用。
關(guān)鍵字: EphA4;EphA4蛋白;EphA4重組蛋白;ACRO;百普賽斯;
百普賽斯集團(tuán)ACROBiosystems Group(股票代碼:301080)是成立于2010年的跨國(guó)生物科技公司,是為全球生物醫(yī)藥、健康產(chǎn)業(yè)領(lǐng)域提供關(guān)鍵生物試劑產(chǎn)品及解決方案的行業(yè)平臺(tái)型基石企業(yè)。2021年在創(chuàng)業(yè)板上市。百普賽斯集團(tuán)業(yè)務(wù)遍布全球,橫跨亞洲、北美洲、歐洲,在中國(guó)、美國(guó)、瑞士等12個(gè)城市設(shè)有辦公室、研發(fā)中心及生產(chǎn)基地。目前累計(jì)服務(wù)客戶超6000家,與全球Top 20醫(yī)藥企業(yè)均建立了長(zhǎng)期、穩(wěn)定的合作伙伴關(guān)系。集團(tuán)旗下?lián)碛衅放艫CROBiosystems百普賽斯、bioSeedin柏思薈、Condense Capital墾拓資本和ACRODiagnostics百斯醫(yī)學(xué)等。