IL-6Rβ產(chǎn)品信息
別稱:gp130,CD130,IL-6Rβ
物種:Human
屬性:Protein
標(biāo)記:Unconjugated
內(nèi)毒素(Endotoxin)
Less than 1.0 EU per μg by the LAL method.
純度(Purity)
>95% as determined by SDS-PAGE.
>90% as determined by SEC-MALS.
制劑(Formulation)
Lyophilized from 0.22 μm filtered solution in PBS, pH7.4 with trehalose as protectant.
Contact us for customized product form or formulation.
重構(gòu)方法(Reconstitution)
Please see Certificate of Analysis for specific instructions.
For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.
存儲(Storage)
For long term storage, the product should be stored at lyophilized state at -20°C or lower.
Please avoid repeated freeze-thaw cycles.
This product is stable after storage at:
-20°C to -70°C for 12 months in lyophilized state;
-70°C for 3 months under sterile conditions after reconstitution.
IL-6Rβ分子背景
白細胞介素-6受體亞基β(IL6ST)也稱為IL-6受體亞基α、IL-6R亞基β、IL-6Rβ、IL-6RB、白細胞介蛋白-6信號轉(zhuǎn)導(dǎo)子、膜糖蛋白130(gp130)、CD130、Oncostatin-M受體亞基a和IL6ST,后者是單程I型膜蛋白。IL6ST/gp130/CD130可以在腦、心臟、胸腺、脾臟、腎臟、肺和肝臟等組織中發(fā)現(xiàn),并且在除BaF-B03之外的所有測試細胞系中都有發(fā)現(xiàn)。IL-6ST/gp130的表達不限于IL6反應(yīng)細胞。IL6、LIF、OSM、CNTF、IL11、CTF1和BSF3的受體系統(tǒng)可以利用gp130啟動信號傳輸。IL6ST/CD130可以與IL6/IL6R(α鏈)復(fù)合物結(jié)合,形成高親和力IL6結(jié)合位點,并轉(zhuǎn)導(dǎo)信號。IL6ST/GP130不結(jié)合IL6,可能在胚胎發(fā)育中發(fā)揮作用。
關(guān)鍵字: IL-6Rβ;IL-6Rβ蛋白;CD130蛋白;ACRO;百普賽斯;
百普賽斯集團ACROBiosystems Group(股票代碼:301080)是成立于2010年的跨國生物科技公司,是為全球生物醫(yī)藥、健康產(chǎn)業(yè)領(lǐng)域提供關(guān)鍵生物試劑產(chǎn)品及解決方案的行業(yè)平臺型基石企業(yè)。2021年在創(chuàng)業(yè)板上市。百普賽斯集團業(yè)務(wù)遍布全球,橫跨亞洲、北美洲、歐洲,在中國、美國、瑞士等12個城市設(shè)有辦公室、研發(fā)中心及生產(chǎn)基地。目前累計服務(wù)客戶超6000家,與全球Top 20醫(yī)藥企業(yè)均建立了長期、穩(wěn)定的合作伙伴關(guān)系。集團旗下?lián)碛衅放艫CROBiosystems百普賽斯、bioSeedin柏思薈、Condense Capital墾拓資本和ACRODiagnostics百斯醫(yī)學(xué)等。