USAG-1產(chǎn)品信息

英文名稱：Sclerostin domain-containing protein 1

中文名稱：含有硬化蛋白結(jié)構(gòu)域的蛋白質(zhì)-1

靶點(diǎn)別稱：USAG-1

物種：Human

屬性：Protein

標(biāo)記：Unconjugated

內(nèi)毒素（Endotoxin）

Less than 1.0 EU per μg by the LAL method.

純度（Purity）

>90% as determined by SDS-PAGE.

制劑（Formulation）

Lyophilized from 0.22 μm filtered solution in 51 mM Tris, 100 mM Glycine, 25 mM Arginine, 150 mM NaCl, pH7.5. Normally trehalose is added as protectant before lyophilization.

Contact us for customized product form or formulation.

重構(gòu)方法（Reconstitution）

Please see Certificate of Analysis for specific instructions.

For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

存儲(chǔ)（Storage）

For long term storage, the product should be stored at lyophilized state at -20°C or lower.

Please avoid repeated freeze-thaw cycles.

This product is stable after storage at:

-20°C to -70°C for 12 months in lyophilized state;

-70°C for 3 months under sterile conditions after reconstitution.

USAG-1分子背景

USAG1（子宮致敏相關(guān)基因1），也稱為SOSTDC1（含硬骨素結(jié)構(gòu)域1），Ectodin，是一種分泌蛋白，其N端糖基化，C端半胱氨酸結(jié)結(jié)構(gòu)域。這種C-末端半胱氨酸結(jié)結(jié)構(gòu)域存在于多種生長(zhǎng)因子中，包括TGFβ、NGF、PDGF、vWF、NDP和粘蛋白-2，并參與二聚化、受體結(jié)合和信號(hào)轉(zhuǎn)導(dǎo)。SOSTDC1在細(xì)胞增殖、分化和凋亡的幾個(gè)生物過(guò)程中負(fù)調(diào)控BMP信號(hào)傳導(dǎo)（如牙形態(tài)發(fā)生、胚胎植入子宮內(nèi)膜和骨折愈合）。此外，SOSTDC1還可能通過(guò)調(diào)節(jié)Wnt途徑參與癌癥的發(fā)展過(guò)程。