NFH產(chǎn)品信息

別稱：NFH,Neurofilament heavy polypeptide

物種：Human

屬性：Protein

標(biāo)記：Unconjugated

內(nèi)毒素（Endotoxin）

Less than 1.0 EU per μg by the LAL method.

純度（Purity）

>95% as determined by SDS-PAGE.

制劑（Formulation）

Lyophilized from 0.22 μm filtered solution in PBS, pH7.4 with trehalose as protectant.

Contact us for customized product form or formulation.

重構(gòu)方法（Reconstitution）

Please see Certificate of Analysis for specific instructions.

For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

存儲(chǔ)（Storage）

For long term storage, the product should be stored at lyophilized state at -20°C or lower.

Please avoid repeated freeze-thaw cycles.

This product is stable after storage at:

-20°C to -70°C for 12 months in lyophilized state;

-70°C for 3 months under sterile conditions after reconstitution.

NFH分子背景

神經(jīng)絲（NF）被歸類為在神經(jīng)元細(xì)胞質(zhì)中發(fā)現(xiàn)的IV型中間絲。它們與微管和微絲一起形成神經(jīng)元細(xì)胞骨架。神經(jīng)絲通常含有三種中間絲蛋白：NFL、NFM和NFH，它們參與維持神經(jīng)元口徑。神經(jīng)絲光（NfL）是一種支架蛋白，主要位于有髓軸突內(nèi)，提供更高的傳導(dǎo)速度和結(jié)構(gòu)支持。近年來，基于軸突損傷導(dǎo)致腦脊液或血液中NfL水平升高的觀察，NfL已被用作疾病生物標(biāo)志物。