GDF2產品信息
英文名稱:Growth/differentiation factor 2
中文名稱:骨形態(tài)發(fā)生蛋白-9
靶點別稱:GDF2,BMP9
物種:Human
屬性:Protein
標記:Unconjugated
內毒素(Endotoxin)
Less than 1.0 EU per μg by the LAL method.
純度(Purity)
>95% as determined by SDS-PAGE.
制劑(Formulation)
Lyophilized from 0.22 μm filtered solution in ACN, TFA in Water with trehalose as protectant.
Contact us for customized product form or formulation.
重構方法(Reconstitution)
Please see Certificate of Analysis for specific instructions.
For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.
存儲(Storage)
For long term storage, the product should be stored at lyophilized state at -20°C or lower.
Please avoid repeated freeze-thaw cycles.
This product is stable after storage at:
-20°C to -70°C for 12 months in lyophilized state;
-70°C for 3 months under sterile conditions after reconstitution.
GDF2分子背景
生長分化因子2(GDF-2),也稱為骨形態(tài)發(fā)生蛋白9(BMP-9),是TGF-β超家族蛋白BMP亞組的成員,通過由I型和II型BMP受體組成的異二聚體復合物發(fā)出信號。GDF-2是血管生成的強效循環(huán)抑制劑。通過I型激活素受體ACVRL1發(fā)出信號,但不通過其他Alks。內皮細胞中通過SMAD1的信號傳導需要TGF-β輔助受體endoglin/ENG。ALK1是內皮細胞(EC)中骨形態(tài)發(fā)生蛋白-9(BMP-9)的信號受體。BMP-9在轉染的COS細胞中與ALK1和endoglin高親和力結合,與I型受體ALK2和BMP II型受體(BMPR-II)和激活素II型受體的結合較弱。當BMPR-II或ActR II共表達時,BMP-9與ALK2的結合大大促進。
關鍵字: GDF2;GDF2蛋白;BMP9蛋白;ACRO;百普賽斯;
百普賽斯集團ACROBiosystems Group(股票代碼:301080)是成立于2010年的跨國生物科技公司,是為全球生物醫(yī)藥、健康產業(yè)領域提供關鍵生物試劑產品及解決方案的行業(yè)平臺型基石企業(yè)。2021年在創(chuàng)業(yè)板上市。百普賽斯集團業(yè)務遍布全球,橫跨亞洲、北美洲、歐洲,在中國、美國、瑞士等12個城市設有辦公室、研發(fā)中心及生產基地。目前累計服務客戶超6000家,與全球Top 20醫(yī)藥企業(yè)均建立了長期、穩(wěn)定的合作伙伴關系。集團旗下?lián)碛衅放艫CROBiosystems百普賽斯、bioSeedin柏思薈、Condense Capital墾拓資本和ACRODiagnostics百斯醫(yī)學等。