GM-CSF R alpha產(chǎn)品信息

英文名稱：Granulocyte-macrophage colony-stimulating factor receptor subunit alpha

中文名稱：粒細(xì)胞-巨噬細(xì)胞集落刺激因子受體α亞基

靶點(diǎn)別稱：GM-CSF R alpha,GM-CSF-R-alpha,GMCSFR-alpha,GMR-alpha,CSF2RA,CSF2R,CSF2RY,CDw116,CD116

物種：Human/Mouse

屬性：Protein

標(biāo)記：Unconjugated

內(nèi)毒素（Endotoxin）

Less than 1.0 EU per μg by the LAL method.

純度（Purity）

>95% as determined by SDS-PAGE.

制劑（Formulation）

Lyophilized from 0.22 μm filtered solution in Tris with Glycine, Arginine and NaCl, pH7.5 with trehalose as protectant.

Contact us for customized product form or formulation.

重構(gòu)方法（Reconstitution）

Please see Certificate of Analysis for specific instructions.

For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

存儲(chǔ)（Storage）

For long term storage, the product should be stored at lyophilized state at -20°C or lower.

Please avoid repeated freeze-thaw cycles.

This product is stable after storage at:

-20°C to -70°C for 12 months in lyophilized state;

-70°C for 3 months under sterile conditions after reconstitution.

GM-CSF R alpha分子背景

GM-CSF Rα（粒細(xì)胞-巨噬細(xì)胞集落刺激因子受體亞基α）也稱為CSF2RA、CD116、GMRα。粒細(xì)胞-巨噬細(xì)胞集落刺激因子低親和力受體。傳遞導(dǎo)致造血細(xì)胞增殖、分化和功能激活的信號(hào)。遺傳性肺泡蛋白沉積癥（hPAP）是一種罕見的肺表面活性物質(zhì)積聚和低氧性呼吸衰竭疾病，由CSF2RA（編碼粒細(xì)胞/巨噬細(xì)胞集落刺激因子[GM-CSF]受體α鏈[CD116]）突變引起，導(dǎo)致肺泡巨噬細(xì)胞對(duì)GM-CSF依賴性肺表面活性物質(zhì)的清除減少。