IL-17C產(chǎn)品信息
別稱:Interleukin-17C,IL-17C,Cytokine CX2,IL17C
物種:Human/Mouse
屬性:Protein
標(biāo)記:Biotin-labeled/Unconjugated
內(nèi)毒素(Endotoxin)
Less than 1.0 EU per μg by the LAL method.
純度(Purity)
>90% as determined by SDS-PAGE.
>90% as determined by SEC-MALS.
制劑(Formulation)
Lyophilized from 0.22 μm filtered solution in PBS, 0.5 M Arginine, pH7.4 with trehalose as protectant.
Contact us for customized product form or formulation.
重構(gòu)方法(Reconstitution)
Please see Certificate of Analysis for specific instructions.
For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.
存儲(Storage)
For long term storage, the product should be stored at lyophilized state at -20°C or lower.
Please avoid repeated freeze-thaw cycles.
This product is stable after storage at:
-20°C to -70°C for 12 months in lyophilized state;
-70°C for 3 months under sterile conditions after reconstitution.
IL-17C分子背景
白細(xì)胞介素-17C(IL-17C)是一種糖基化細(xì)胞因子,在粘膜免疫和慢性炎癥中起著重要作用。IL-17C與IL-17RE以高親和力結(jié)合,與IL-17RA以低親和力結(jié)合,并與IL17RA和IL17RE形成的異二聚體結(jié)合。增強(qiáng)的IL17C/IL17RE信號傳導(dǎo)也可能導(dǎo)致對自身免疫性疾病的易感性增加。通過NF-kappa-B和MAPK途徑發(fā)出信號,刺激抗菌肽和促炎分子的產(chǎn)生,用于宿主防御。與IL22協(xié)同作用,誘導(dǎo)抗菌肽的表達(dá),包括S100A8、S100A9、REG3A和REG3G。在誘導(dǎo)角質(zhì)形成細(xì)胞產(chǎn)生DEFB2的過程中,也觀察到TNF和IL1B的協(xié)同作用。
關(guān)鍵字: IL-17C;IL-17C蛋白;IL-17C重組蛋白;ACRO;百普賽斯;
百普賽斯集團(tuán)ACROBiosystems Group(股票代碼:301080)是成立于2010年的跨國生物科技公司,是為全球生物醫(yī)藥、健康產(chǎn)業(yè)領(lǐng)域提供關(guān)鍵生物試劑產(chǎn)品及解決方案的行業(yè)平臺型基石企業(yè)。2021年在創(chuàng)業(yè)板上市。百普賽斯集團(tuán)業(yè)務(wù)遍布全球,橫跨亞洲、北美洲、歐洲,在中國、美國、瑞士等12個城市設(shè)有辦公室、研發(fā)中心及生產(chǎn)基地。目前累計服務(wù)客戶超6000家,與全球Top 20醫(yī)藥企業(yè)均建立了長期、穩(wěn)定的合作伙伴關(guān)系。集團(tuán)旗下?lián)碛衅放艫CROBiosystems百普賽斯、bioSeedin柏思薈、Condense Capital墾拓資本和ACRODiagnostics百斯醫(yī)學(xué)等。