CLEC5A產(chǎn)品信息

別稱(chēng)：CLEC5A,MDL1

物種：Human

屬性：Protein

標(biāo)記：Unconjugated

內(nèi)毒素（Endotoxin）

Less than 1.0 EU per μg by the LAL method.

純度（Purity）

>95% as determined by SDS-PAGE.

>90% as determined by SEC-MALS.

制劑（Formulation）

Lyophilized from 0.22 μm filtered solution in PBS, pH7.4 with trehalose as protectant.

Contact us for customized product form or formulation.

重構(gòu)方法（Reconstitution）

Please see Certificate of Analysis for specific instructions.

For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

存儲(chǔ)（Storage）

For long term storage, the product should be stored at lyophilized state at -20°C or lower.

Please avoid repeated freeze-thaw cycles.

This product is stable after storage at:

-20°C to -70°C for 12 months in lyophilized state;

-70°C for 3 months under sterile conditions after reconstitution.

CLEC5A分子背景

CLEC5A，也稱(chēng)為MDL1和MDL-1，是C型凝集素/C型凝集素樣結(jié)構(gòu)域（CTL/CTLD）超家族的成員。CLEC5A在單核細(xì)胞、巨噬細(xì)胞和中性粒細(xì)胞上表達(dá)。在類(lèi)風(fēng)濕性關(guān)節(jié)炎中，其在單核細(xì)胞上的表達(dá)上調(diào)。CLEC5A與dnax活化蛋白12結(jié)合，可能在細(xì)胞活化中發(fā)揮作用。它還具有破骨細(xì)胞生成的積極調(diào)節(jié)作用。CLEC5A是自身免疫性關(guān)節(jié)炎癥期間滑膜損傷和骨侵蝕的關(guān)鍵調(diào)節(jié)因子。登革熱病毒與CLEC5A的結(jié)合通過(guò)TYROBP的磷酸化觸發(fā)信號(hào)傳導(dǎo)，這種相互作用不會(huì)導(dǎo)致病毒進(jìn)入，但會(huì)刺激促炎細(xì)胞因子的釋放。