LRP-5產(chǎn)品信息

英文名稱：Low-density lipoprotein receptor-related protein 5

中文名稱：低密度脂蛋白受體相關(guān)蛋白5

靶點(diǎn)別稱：LRP5,LRP-5,LRP-7,LRP7,LR3

物種：Human

屬性：Protein

標(biāo)記：Biotin-labeled/Unconjugated

內(nèi)毒素（Endotoxin）

Less than 0.1 EU per μg by the LAL method.

純度（Purity）

>95% as determined by SDS-PAGE.

制劑（Formulation）

Lyophilized from 0.22 μm filtered solution in 51 mM Tris, 100 mM Glycine, 25 mM Arginine, 150 mM NaCl, pH7.5 with trehalose as protectant.

Contact us for customized product form or formulation.

重構(gòu)方法（Reconstitution）

Please see Certificate of Analysis for specific instructions.

For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

存儲(chǔ)（Storage）

For long term storage, the product should be stored at lyophilized state at -20°C or lower.

Please avoid repeated freeze-thaw cycles.

This product is stable after storage at:

-20°C to -70°C for 12 months in lyophilized state;

-70°C for 3 months under sterile conditions after reconstitution.

LRP-5分子背景

低密度脂蛋白受體相關(guān)蛋白5（LRP-5）也被稱為BMND1、EVR1、EVR4、HBM、LR3、LRP7、OPPG、OPTA1、VBCH2、LDL受體相關(guān)蛋白五和PCLD4。LRP5是一種跨膜低密度脂蛋白受體，與LRP6具有相似的結(jié)構(gòu)。LRP5作為LRP6和卷曲蛋白家族成員的共受體，通過經(jīng)典Wnt通路由Wnt蛋白轉(zhuǎn)導(dǎo)信號(hào)。這種蛋白質(zhì)在骨骼穩(wěn)態(tài)中起著關(guān)鍵作用。LRP5突變可導(dǎo)致骨量發(fā)生相當(dāng)大的變化。功能喪失突變會(huì)導(dǎo)致骨質(zhì)疏松癥假性膠質(zhì)瘤（骨量減少），而功能獲得突變會(huì)導(dǎo)致骨量急劇增加。