NKG2A產(chǎn)品信息

英文名稱：NK cell lectin-like receptor subfamily C member 1

中文名稱：自然殺傷細(xì)胞凝集素樣受體亞家族C成員1

靶點(diǎn)別稱：NKG2A,CD159a,KLRC1,NK cell receptor A

物種：Human/Mouse/Cynomolgus

屬性：Protein

標(biāo)記：Unconjugated

內(nèi)毒素（Endotoxin）

Less than 1.0 EU per μg by the LAL method.

純度（Purity）

>90% as determined by SDS-PAGE.

制劑（Formulation）

Lyophilized from 0.22 μm filtered solution in PBS, pH7.4. Normally trehalose is added as protectant before lyophilization.

Contact us for customized product form or formulation.

重構(gòu)方法（Reconstitution）

Please see Certificate of Analysis for specific instructions.

For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

存儲(chǔ)（Storage）

For long term storage, the product should be stored at lyophilized state at -20°C or lower.

Please avoid repeated freeze-thaw cycles.

This product is stable after storage at:

-20°C to -70°C for 12 months in lyophilized state;

-70°C for 3 months under sterile conditions after reconstitution.

NKG2A用戶評(píng)價(jià)

NKG2A分子背景

NKG2A/CD159a是一種跨膜蛋白，屬于CD94/NKG2家族的C型凝集素樣受體，可抑制先天免疫系統(tǒng)激活，也稱為KLRC1、CD159a、NK細(xì)胞受體a和NKG2-a/NKG2-B II型整合膜蛋白。NKG2A標(biāo)記了一種獨(dú)特的免疫效應(yīng)子亞群，優(yōu)先共表達(dá)組織駐留CD103分子，但不表達(dá)免疫檢查點(diǎn)抑制劑。NKG2A阻斷療法通過(guò)CD8 T細(xì)胞而非NK細(xì)胞進(jìn)行。NKG2A表達(dá)的增加可能是由IL-10誘導(dǎo)的，IL-10在HCC患者的血漿中高水平存在。阻斷IL-10可以特異性抑制NK細(xì)胞中NKG2A的表達(dá)。這些發(fā)現(xiàn)表明，NKG2A的表達(dá)受癌癥巢因子的影響，并導(dǎo)致NK細(xì)胞耗竭，這表明NKG2A阻斷有可能通過(guò)逆轉(zhuǎn)NK細(xì)胞耗竭來(lái)恢復(fù)對(duì)肝腫瘤的免疫力。