CD79A&CD79B產(chǎn)品信息

英文名稱：B-cell antigen receptor complex-associated protein beta chain

中文名稱：B細(xì)胞抗原受體復(fù)合物相關(guān)蛋白β鏈

靶點別稱：CD79A&CD79B

物種：Human/Cynomolgus

屬性：Protein/Cell

標(biāo)記：Unconjugated

內(nèi)毒素（Endotoxin）

Less than 0.1 EU per μg by the LAL method.

純度（Purity）

>95% as determined by SDS-PAGE.

制劑（Formulation）

Lyophilized from 0.22 μm filtered solution in 50 mM Tris, 100 mM Glycine, 25 mM Arginine, 150 mM NaCl, pH7.5 with trehalose as protectant.

Contact us for customized product form or formulation.

重構(gòu)方法（Reconstitution）

Please see Certificate of Analysis for specific instructions.

For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

存儲（Storage）

For long term storage, the product should be stored at lyophilized state at -20°C or lower.

Please avoid repeated freeze-thaw cycles.

This product is stable after storage at:

-20°C to -70°C for 12 months in lyophilized state;

-70°C for 3 months under sterile conditions after reconstitution.

CD79A&CD79B分子背景

CD79a和CD79b異二聚體是B細(xì)胞受體（BCR）復(fù)合物的重要信號成分，在B細(xì)胞發(fā)育和抗體產(chǎn)生中起著至關(guān)重要的作用。BCR復(fù)合物由與信號成分非共價結(jié)合的配體結(jié)合受體（膜免疫球蛋白；mIg）、CD79a（Igα）和CD79b（Igβ）的二硫鍵連接異二聚體組成。這兩種CD79亞基都由一個Ig樣結(jié)構(gòu)域、一個跨膜（TM）區(qū)域和一個較長的細(xì)胞質(zhì)尾部（CYT）組成，該尾部包含一個基于免疫受體酪氨酸的激活基序（ITAM）。