中文名:甲氧基X04
英文名:Methoxy-X04
中文別名:2,5-雙(2-(4-羥苯基)乙烯基)茴香醚|4,4'-[(2-甲氧基-1,4-亞苯基)二- (1E)-2,1-亞乙基]雙-苯酚
純度:≥97%
貨號(hào):M276110
包裝:25mg、5mg、1mg
Cas號(hào):863918-78-9
存儲(chǔ)溫度:-20°C儲(chǔ)存
產(chǎn)品介紹:
Description:
Methoxy-X04 is a brain-permeable fluorescent probe for amyloid-β (Aβ) to detect and quantify plaques, tangles, and cerebrovascular amyloid.1 It displays high in vitro binding affinity (Ki = 26.8 nM) for fibrillar β-sheet deposits and is used to image Aβ plaques in the brains of living APP/PS1 mice, a transgenic model of familial Alzheimer's disease.1,2 For in vivo imaging, APP/PS1 mice were injected with methoxy-X04 at a dose of 10 mg/kg, i.p., 24 hours prior to two-photon imaging.2 Methoxy-X04 displays an excitation peak at 750 nm with emission between 460 and 500 nm.2
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關(guān)鍵字: 2,5-雙(2-(4-羥苯基)乙烯基)茴香醚;4,4'-[(2-甲氧基-1,4-亞苯基)二- (1E)-2,1-亞乙基]雙-苯酚
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