IL-22產(chǎn)品信息

英文名稱：Interleukin-22

中文名稱：白細(xì)胞介素-22

靶點(diǎn)別稱：IL-22,IL-TIF,ZCYTO18

物種：Human

屬性：Protein

標(biāo)記：Biotin-labeled/Unconjugated

內(nèi)毒素（Endotoxin）

Less than 1.0 EU per μg by the LAL method.

純度（Purity）

>90% as determined by SDS-PAGE.

制劑（Formulation）

Lyophilized from 0.22 μm filtered solution in PBS, pH7.4 with trehalose as protectant.

Contact us for customized product form or formulation.

重構(gòu)方法（Reconstitution）

Please see Certificate of Analysis for specific instructions.

For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

存儲(chǔ)（Storage）

For long term storage, the product should be stored at lyophilized state at -20°C or lower.

Please avoid repeated freeze-thaw cycles.

This product is stable after storage at:

-20°C to -70°C for 12 months in lyophilized state;

-70°C for 3 months under sterile conditions after reconstitution.

IL-22分子背景

白細(xì)胞介素-22（IL-22）也稱為細(xì)胞因子Zcyto18、IL-10相關(guān)T細(xì)胞衍生誘導(dǎo)因子（IL-TIF），屬于IL-10家族或IL-10超家族（包括IL-19、IL-20、IL-24和IL-26），是一類強(qiáng)效的細(xì)胞炎癥反應(yīng)介質(zhì)。IL-22由活化的DC和T細(xì)胞產(chǎn)生，并啟動(dòng)針對(duì)細(xì)菌病原體的先天免疫反應(yīng)，特別是在呼吸道和腸道上皮細(xì)胞等上皮細(xì)胞中。IL-22的生物活性是通過與由IL-22R1和IL-10R2受體鏈組成的細(xì)胞表面復(fù)合物結(jié)合而啟動(dòng)的，并通過與可溶性結(jié)合蛋白IL-22BP的相互作用進(jìn)一步調(diào)節(jié)。IL-22還促進(jìn)肝臟中的肝細(xì)胞存活以及肺和腸道中的上皮細(xì)胞，類似于IL-10。