MAG/Siglec-4a產(chǎn)品信息

英文名稱：Myelin-associated glycoprotein

中文名稱：髓磷脂相關(guān)糖蛋白

靶點(diǎn)別稱：MAG,Siglec-4a,GMA,S-MAG

物種：Human/Mouse

屬性：Protein

標(biāo)記：Biotin-labeled/Unconjugated

內(nèi)毒素（Endotoxin）

Less than 1.0 EU per μg by the LAL method.

純度（Purity）

>95% as determined by SDS-PAGE.

制劑（Formulation）

Lyophilized from 0.22 μm filtered solution in PBS, pH7.4 with trehalose as protectant.

Contact us for customized product form or formulation.

重構(gòu)方法（Reconstitution）

Please see Certificate of Analysis for specific instructions.

For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

存儲（Storage）

For long term storage, the product should be stored at lyophilized state at -20°C or lower.

Please avoid repeated freeze-thaw cycles.

This product is stable after storage at:

-20°C to -70°C for 12 months in lyophilized state;

-70°C for 3 months under sterile conditions after reconstitution.

MAG/Siglec-4a分子背景

髓磷脂相關(guān)糖蛋白（MAG）是一種神經(jīng)系統(tǒng)細(xì)胞粘附分子，是一種I型凝集素，與唾液酸化的糖復(fù)合物結(jié)合，包括具有特征性結(jié)構(gòu)決定因素的神經(jīng)節(jié)苷脂。優(yōu)先與α-2,3-連接的唾液酸結(jié)合。結(jié)合神經(jīng)節(jié)苷脂Gt1b。粘附分子，通過與含神經(jīng)元唾液酸的神經(jīng)節(jié)苷脂和糖蛋白RTN4R和RTN4RL2結(jié)合，介導(dǎo)髓鞘形成細(xì)胞和神經(jīng)元之間的相互作用。對凋亡的保護(hù)可能是通過與神經(jīng)元RTN4R和RTN4RL2的相互作用介導(dǎo)的。在背根神經(jīng)節(jié)神經(jīng)元中，抑制主要通過與神經(jīng)元RTN4R或RTN4RL2結(jié)合介導(dǎo)，在較小程度上通過與神經(jīng)元神經(jīng)節(jié)苷脂結(jié)合介導(dǎo)。在小腦顆粒細(xì)胞中，抑制主要通過與神經(jīng)元神經(jīng)節(jié)苷脂的結(jié)合來介導(dǎo)。在感覺神經(jīng)元中，神經(jīng)突起延伸的抑制僅部分取決于RTN4R、RTN4RL2和神經(jīng)節(jié)苷脂。