TGF-beta 3產(chǎn)品信息

英文名稱：Transforming growth factor beta 3

中文名稱：轉(zhuǎn)化生長(zhǎng)因子β3

靶點(diǎn)別稱：TGFB3,ARVD,TGF-beta3

物種：Human

屬性：Protein

標(biāo)記：Unconjugated

內(nèi)毒素（Endotoxin）

Less than 0.1 EU per μg by the LAL method.

無(wú)菌（Sterility）

The sterility testing was performed by membrane filtration method.

支原體（Mycoplasma）

Negative.

純度（Purity）

>95% as determined by SDS-PAGE.

制劑（Formulation）

Lyophilized from 0.22 μm filtered solution in 50 mM HAC, pH2.8 with trehalose as protectant.

Contact us for customized product form or formulation.

重構(gòu)方法（Reconstitution）

Please see Certificate of Analysis for specific instructions.

For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

存儲(chǔ)（Storage）

For long term storage, the product should be stored at lyophilized state at -20°C or lower.

Please avoid repeated freeze-thaw cycles.

This product is stable after storage at:

-20°C to -70°C for 12 months in lyophilized state;

-70°C for 3 months under sterile conditions after reconstitution.

TGF-beta 3分子背景

轉(zhuǎn)化生長(zhǎng)因子β3（TGFB3）也稱為TGF-β3，是轉(zhuǎn)化生長(zhǎng)因子-β超家族細(xì)胞因子的多肽成員。它是一種分泌的蛋白質(zhì)，執(zhí)行許多細(xì)胞功能，包括調(diào)節(jié)胚胎發(fā)生和細(xì)胞分化，是次級(jí)腭發(fā)育等各種過(guò)程所必需的。TGF-β3與TGF-β1和-β2相似，充當(dāng)細(xì)胞開(kāi)關(guān)，調(diào)節(jié)免疫功能、細(xì)胞增殖和上皮間質(zhì)轉(zhuǎn)化。整合素從LAP釋放TGF-β-3：整合素結(jié)合導(dǎo)致LAP鏈扭曲，隨后釋放活性TGF-β-3。一旦LAP釋放后被激活，TGF-β-3通過(guò)與TGF-β受體（TGFBR1和TGFBR2）結(jié)合起作用，TGF-β受體負(fù)責(zé)轉(zhuǎn)導(dǎo)信號(hào)。