Siglec-15產(chǎn)品信息
英文名稱:Sialic acid-binding Ig-like lectin 15
中文名稱:唾液酸結(jié)合免疫球蛋白樣凝集素-15
靶點(diǎn)別稱:CD33 antigen-like 3,SIGLEC-15,CD33L3,sialic acid-binding Ig-like lectin 15,Siglec15,Siglec-15
物種:Human/Mouse/Cynomolgus
屬性:Protein/Cell
標(biāo)記:Biotin-labeled/Unconjugated
內(nèi)毒素(Endotoxin)
Less than 1.0 EU per μg by the LAL method.
純度(Purity)
>90% as determined by SDS-PAGE.
制劑(Formulation)
Lyophilized from 0.22 μm filtered solution in 25 mM MES, 150 mM NaCl, pH7.5. Normally trehalose is added as protectant before lyophilization.
Contact us for customized product form or formulation.
重構(gòu)方法(Reconstitution)
Please see Certificate of Analysis for specific instructions.
For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.
存儲(chǔ)(Storage)
For long term storage, the product should be stored at lyophilized state at -20°C or lower.
Please avoid repeated freeze-thaw cycles.
This product is stable after storage at:
-20°C to -70°C for 24 months in lyophilized state;
-70°C for 12 months under sterile conditions after reconstitution.
Siglec-15用戶評(píng)價(jià)
Siglec-15分子背景
Siglec-15是一種DAP12相關(guān)的免疫受體,屬于免疫球蛋白超家族和Siglec(唾液酸結(jié)合Ig樣凝集素)家族。Siglecs是結(jié)合唾液酸的細(xì)胞表面蛋白。它們主要存在于免疫細(xì)胞的表面,是I型凝集素的一個(gè)子集。Siglec-15由免疫球蛋白(Ig)樣結(jié)構(gòu)域、跨膜結(jié)構(gòu)域和短細(xì)胞質(zhì)尾部組成。Siglec-15識(shí)別唾液酸化聚糖并調(diào)節(jié)破骨細(xì)胞分化。Siglec-15是骨質(zhì)疏松癥的潛在治療靶點(diǎn),在脊椎動(dòng)物的免疫系統(tǒng)中起著保守的調(diào)節(jié)作用。
關(guān)鍵字: Siglec-15;Siglec-15蛋白;SIGLEC15;CD33L3;百普賽斯;
百普賽斯集團(tuán)ACROBiosystems Group(股票代碼:301080)是成立于2010年的跨國生物科技公司,是為全球生物醫(yī)藥、健康產(chǎn)業(yè)領(lǐng)域提供關(guān)鍵生物試劑產(chǎn)品及解決方案的行業(yè)平臺(tái)型基石企業(yè)。2021年在創(chuàng)業(yè)板上市。百普賽斯集團(tuán)業(yè)務(wù)遍布全球,橫跨亞洲、北美洲、歐洲,在中國、美國、瑞士等12個(gè)城市設(shè)有辦公室、研發(fā)中心及生產(chǎn)基地。目前累計(jì)服務(wù)客戶超6000家,與全球Top 20醫(yī)藥企業(yè)均建立了長(zhǎng)期、穩(wěn)定的合作伙伴關(guān)系。集團(tuán)旗下?lián)碛衅放艫CROBiosystems百普賽斯、bioSeedin柏思薈、Condense Capital墾拓資本和ACRODiagnostics百斯醫(yī)學(xué)等。