E-Cadherin產(chǎn)品信息

英文名稱：Cadherin-1

中文名稱：鈣粘蛋白-1

靶點(diǎn)別稱：Cadherin-1,CDH1,CD324,E-cadherin,Arc-1,ECAD,LCAM,UVO

物種：Human

屬性：Protein

標(biāo)記：Unconjugated

內(nèi)毒素（Endotoxin）

Less than 0.1 EU per μg by the LAL method.

無(wú)菌（Sterility）

The sterility testing was performed by membrane filtration method.

支原體（Mycoplasma）

Negative.

純度（Purity）

>95% as determined by SDS-PAGE.

制劑（Formulation）

Lyophilized from 0.22 μm filtered solution in 50 mM Tris, 100 mM Glycine, pH7.5 with trehalose as protectant.

Contact us for customized product form or formulation.

重構(gòu)方法（Reconstitution）

Please see Certificate of Analysis for specific instructions.

For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

存儲(chǔ)（Storage）

For long term storage, the product should be stored at lyophilized state at -20°C or lower.

Please avoid repeated freeze-thaw cycles.

This product is stable after storage at:

-20°C to -70°C for 12 months in lyophilized state;

-70°C for 3 months under sterile conditions after reconstitution.

E-Cadherin分子背景

Cadherins是鈣依賴性細(xì)胞粘附蛋白。它們?cè)谶B接細(xì)胞時(shí)優(yōu)先以親同的方式與自己相互作用；鈣粘蛋白因此可能有助于異質(zhì)細(xì)胞類型的分選。鈣粘蛋白-1（CDH1）也稱為上皮鈣粘蛋白（E-Cadherin）、CD_抗原（CD324）、UVO ECAD和CDHE，CDH1/CD324包含5個(gè)鈣粘蛋白結(jié)構(gòu)域。CDH1/CD324/ECAD在非神經(jīng)上皮組織中表達(dá)。CDH1/E-CAD參與調(diào)節(jié)上皮細(xì)胞的細(xì)胞間粘附、遷移和增殖的機(jī)制，并具有強(qiáng)大的侵襲抑制作用。它是整合素α-E/β-7的配體。E-Cad促進(jìn)Abeta前體的非淀粉樣降解，對(duì)APP C99和C83的產(chǎn)生具有很強(qiáng)的抑制作用。CDH1/CD324/ECAD缺陷是遺傳性彌漫性癌癥（HDGC）的病因。